Search Results
Overview
| Uniprot ID | Q16831 |
|---|---|
| Protein Name | Uridine phosphorylase 1 |
| Gene Name | UPP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 174 | FEQIVLGKRVIRKTD |
| 230 | ALCSYTEKDKQAYLE |
| 232 | CSYTEKDKQAYLEAA |
Function
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:7488099). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (Probable)
Protein Sequence
10
MAATGANAEK
20
AESHNDCPVR
30
LLNPNIAKMK
40
EDILYHFNLT
50
TSRHNFPALF
60
GDVKFVCVGG
70
SPSRMKAFIR
80
CVGAELGLDC
90
PGRDYPNICA
100
GTDRYAMYKV
110
GPVLSVSHGM
120
GIPSISIMLH
130
ELIKLLYYAR
140
CSNVTIIRIG
150
TSGGIGLEPG
160
TVVITEQAVD
170
TCFKAEFEQI
180
VLGKRVIRKT
190
DLNKKLVQEL
200
LLCSAELSEF
210
TTVVGNTMCT
220
LDFYEGQGRL
230
DGALCSYTEK
240
DKQAYLEAAY
250
AAGVRNIEME
260
SSVFAAMCSA
270
CGLQAAVVCV
280
TLLNRLEGDQ
290
ISSPRNVLSE
300
YQQRPQRLVS
310
YFIKKKLSKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0047847 | deoxyuridine phosphorylase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0009032 | thymidine phosphorylase activity |
| Molecular Function | GO:0004850 | uridine phosphorylase activity |
| Biological Process | GO:0042149 | cellular response to glucose starvation |
| Biological Process | GO:0006248 | CMP catabolic process |
| Biological Process | GO:0006249 | dCMP catabolic process |
| Biological Process | GO:0046074 | dTMP catabolic process |
| Biological Process | GO:0046079 | dUMP catabolic process |
| Biological Process | GO:0006139 | nucleobase-containing compound metabolic process |
| Biological Process | GO:0046050 | UMP catabolic process |
| Biological Process | GO:0044206 | UMP salvage |
| Biological Process | GO:0006218 | uridine catabolic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.