Search Results

Overview

Uniprot IDQ16836
Protein NameHydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Gene NameHADH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
127 IVENLKVKNELFKRL
179 FNPVPVMKLVEVIKT
185 MKLVEVIKTPMTSQK
192 KTPMTSQKTFESLVD
202 ESLVDFSKALGKHPV
206 DFSKALGKHPVSCKD
212 GKHPVSCKDTPGFIV
241 YERGDASKEDIDTAM
301 NKLVAENKFGKKTGE
305 AENKFGKKTGEGFYK
312 KTGEGFYKYK*****
68 DILAKSKKGIEESLR
81 LRKVAKKKFAENLKA
87 KKFAENLKAGDEFVE

Function

Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity)

Protein Sequence

10 MAFVTRQFMR 20 SVSSSSTASA 30 SAKKIIVKHV 40 TVIGGGLMGA 50 GIAQVAAATG 60 HTVVLVDQTE 70 DILAKSKKGI 80 EESLRKVAKK 90 KFAENLKAGD 100 EFVEKTLSTI 110 ATSTDAASVV 120 HSTDLVVEAI 130 VENLKVKNEL 140 FKRLDKFAAE 150 HTIFASNTSS 160 LQITSIANAT 170 TRQDRFAGLH 180 FFNPVPVMKL 190 VEVIKTPMTS 200 QKTFESLVDF 210 SKALGKHPVS 220 CKDTPGFIVN 230 RLLVPYLMEA 240 IRLYERGDAS 250 KEDIDTAMKL 260 GAGYPMGPFE 270 LLDYVGLDTT 280 KFIVDGWHEM 290 DAENPLHQPS 300 PSLNKLVAEN 310 KFGKKTGEGF YKYK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0003857 (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0070403 NAD+ binding
Molecular Function GO:0016740 transferase activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0014823 response to activity
Biological Process GO:0032868 response to insulin
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.