Search Results

Overview

Uniprot IDQ16851
Protein NameUTP--glucose-1-phosphate uridylyltransferase
Gene NameUGP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 RFVQDLSKAMSQDGA
107 NISSVLNKLVVVKLN
112 LNKLVVVKLNGGLGT
124 LGTSMGCKGPKSLIG
127 SMGCKGPKSLIGVRN
177 DTKKILQKYNHCRVK
184 KYNHCRVKIYTFNQS
198 SRYPRINKESLLPVA
291 NKTRADVKGGTLTQY
301 TLTQYEGKLRLVEIA
312 VEIAQVPKAHVDEFK
319 KAHVDEFKSVSKFKI
33 QELELSVKKELEKIL
34 ELELSVKKELEKILT
38 SVKKELEKILTTASS
431 FPTVPLVKLGSSFTK
438 KLGSSFTKVQDYLRR
473 FGKNVSLKGTVIIIA
52 SHEFEHTKKDLDGFR
53 HEFEHTKKDLDGFRK
69 FHRFLQEKGPSVDWG
91 DSIQPYEKIKARGLP

Function

UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen

Protein Sequence

10 MSRFVQDLSK 20 AMSQDGASQF 30 QEVIRQELEL 40 SVKKELEKIL 50 TTASSHEFEH 60 TKKDLDGFRK 70 LFHRFLQEKG 80 PSVDWGKIQR 90 PPEDSIQPYE 100 KIKARGLPDN 110 ISSVLNKLVV 120 VKLNGGLGTS 130 MGCKGPKSLI 140 GVRNENTFLD 150 LTVQQIEHLN 160 KTYNTDVPLV 170 LMNSFNTDED 180 TKKILQKYNH 190 CRVKIYTFNQ 200 SRYPRINKES 210 LLPVAKDVSY 220 SGENTEAWYP 230 PGHGDIYASF 240 YNSGLLDTFI 250 GEGKEYIFVS 260 NIDNLGATVD 270 LYILNHLMNP 280 PNGKRCEFVM 290 EVTNKTRADV 300 KGGTLTQYEG 310 KLRLVEIAQV 320 PKAHVDEFKS 330 VSKFKIFNTN 340 NLWISLAAVK 350 RLQEQNAIDM 360 EIIVNAKTLD 370 GGLNVIQLET 380 AVGAAIKSFE 390 NSLGINVPRS 400 RFLPVKTTSD 410 LLLVMSNLYS 420 LNAGSLTMSE 430 KREFPTVPLV 440 KLGSSFTKVQ 450 DYLRRFESIP 460 DMLELDHLTV 470 SGDVTFGKNV 480 SLKGTVIIIA 490 NHGDRIDIPP 500 GAVLENKIVS GNLRILDH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity
Biological Process GO:0007420 brain development
Biological Process GO:0005978 glycogen biosynthetic process
Biological Process GO:0005977 glycogen metabolic process
Biological Process GO:0006011 UDP-alpha-D-glucose metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.