Overview
| Uniprot ID | Q16853 |
|---|
| Protein Name | Amine oxidase [copper-containing] 3 |
|---|
| Gene Name | AOC3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 393 |
DGGFGMGKYTTPLTR |
Function
Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, PubMed:24304424, PubMed:9653080). Has a preference for the primary monoamines methylamine and benzylamine (PubMed:19588076, PubMed:9653080). Could also act on 2-phenylethylamine but much less efficiently (PubMed:19588076). At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion (PubMed:9254657, PubMed:9653080)
Protein Sequence
10
MNQKTILVLL
20
ILAVITIFAL
30
VCVLLVGRGG
40
DGGEPSQLPH
50
CPSVSPSAQP
60
WTHPGQSQLF
70
ADLSREELTA
80
VMRFLTQRLG
90
PGLVDAAQAR
100
PSDNCVFSVE
110
LQLPPKAAAL
120
AHLDRGSPPP
130
AREALAIVFF
140
GRQPQPNVSE
150
LVVGPLPHPS
160
YMRDVTVERH
170
GGPLPYHRRP
180
VLFQEYLDID
190
QMIFNRELPQ
200
ASGLLHHCCF
210
YKHRGRNLVT
220
MTTAPRGLQS
230
GDRATWFGLY
240
YNISGAGFFL
250
HHVGLELLVN
260
HKALDPARWT
270
IQKVFYQGRY
280
YDSLAQLEAQ
290
FEAGLVNVVL
300
IPDNGTGGSW
310
SLKSPVPPGP
320
APPLQFYPQG
330
PRFSVQGSRV
340
ASSLWTFSFG
350
LGAFSGPRIF
360
DVRFQGERLV
370
YEISLQEALA
380
IYGGNSPAAM
390
TTRYVDGGFG
400
MGKYTTPLTR
410
GVDCPYLATY
420
VDWHFLLESQ
430
APKTIRDAFC
440
VFEQNQGLPL
450
RRHHSDLYSH
460
YFGGLAETVL
470
VVRSMSTLLN
480
YDYVWDTVFH
490
PSGAIEIRFY
500
ATGYISSAFL
510
FGATGKYGNQ
520
VSEHTLGTVH
530
THSAHFKVDL
540
DVAGLENWVW
550
AEDMVFVPMA
560
VPWSPEHQLQ
570
RLQVTRKLLE
580
MEEQAAFLVG
590
SATPRYLYLA
600
SNHSNKWGHP
610
RGYRIQMLSF
620
AGEPLPQNSS
630
MARGFSWERY
640
QLAVTQRKEE
650
EPSSSSVFNQ
660
NDPWAPTVDF
670
SDFINNETIA
680
GKDLVAWVTA
690
GFLHIPHAED
700
IPNTVTVGNG
710
VGFFLRPYNF
720
FDEDPSFYSA
730
DSIYFRGDQD
740
AGACEVNPLA
750
CLPQAAACAP
760
DLPAFSHGGF
SHN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005902 |
microvillus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0005507 |
copper ion binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008131 |
primary methylamine oxidase activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0048038 |
quinone binding |
| Biological Process |
GO:0009308 |
amine metabolic process |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0006954 |
inflammatory response |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.