Search Results
Overview
| Uniprot ID | Q16854 |
|---|---|
| Protein Name | Deoxyguanosine kinase, mitochondrial |
| Gene Name | DGUOK |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | EKLLQARKPVQIFER |
| 275 | REVNTFVKNL***** |
Function
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:11687801, PubMed:17073823, PubMed:23043144, PubMed:8692979, PubMed:8706825). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents
Protein Sequence
10
MAAGRLFLSR
20
LRAPFSSMAK
30
SPLEGVSSSR
40
GLHAGRGPRR
50
LSIEGNIAVG
60
KSTFVKLLTK
70
TYPEWHVATE
80
PVATWQNIQA
90
AGTQKACTAQ
100
SLGNLLDMMY
110
REPARWSYTF
120
QTFSFLSRLK
130
VQLEPFPEKL
140
LQARKPVQIF
150
ERSVYSDRYI
160
FAKNLFENGS
170
LSDIEWHIYQ
180
DWHSFLLWEF
190
ASRITLHGFI
200
YLQASPQVCL
210
KRLYQRAREE
220
EKGIELAYLE
230
QLHGQHEAWL
240
IHKTTKLHFE
250
ALMNIPVLVL
260
DVNDDFSEEV
270
TKQEDLMREV
NTFVKNL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004136 | deoxyadenosine kinase activity |
| Molecular Function | GO:0004138 | deoxyguanosine kinase activity |
| Biological Process | GO:0106383 | dAMP salvage |
| Biological Process | GO:0008617 | guanosine metabolic process |
| Biological Process | GO:0042775 | mitochondrial ATP synthesis coupled electron transport |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0046122 | purine deoxyribonucleoside metabolic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.