Search Results
Overview
| Uniprot ID | Q16875 |
|---|---|
| Protein Name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
| Gene Name | PFKFB3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 97 | PDNEEAMKVRKQCAL |
Function
Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate
Protein Sequence
10
MPLELTQSRV
20
QKIWVPVDHR
30
PSLPRSCGPK
40
LTNSPTVIVM
50
VGLPARGKTY
60
ISKKLTRYLN
70
WIGVPTKVFN
80
VGEYRREAVK
90
QYSSYNFFRP
100
DNEEAMKVRK
110
QCALAALRDV
120
KSYLAKEGGQ
130
IAVFDATNTT
140
RERRHMILHF
150
AKENDFKAFF
160
IESVCDDPTV
170
VASNIMEVKI
180
SSPDYKDCNS
190
AEAMDDFMKR
200
ISCYEASYQP
210
LDPDKCDRDL
220
SLIKVIDVGR
230
RFLVNRVQDH
240
IQSRIVYYLM
250
NIHVQPRTIY
260
LCRHGENEHN
270
LQGRIGGDSG
280
LSSRGKKFAS
290
ALSKFVEEQN
300
LKDLRVWTSQ
310
LKSTIQTAEA
320
LRLPYEQWKA
330
LNEIDAGVCE
340
ELTYEEIRDT
350
YPEEYALREQ
360
DKYYYRYPTG
370
ESYQDLVQRL
380
EPVIMELERQ
390
ENVLVICHQA
400
VLRCLLAYFL
410
DKSAEEMPYL
420
KCPLHTVLKL
430
TPVAYGCRVE
440
SIYLNVESVC
450
THRERSEDAK
460
KGPNPLMRRN
470
SVTPLASPEP
480
TKKPRINSFE
490
EHVASTSAAL
500
PSCLPPEVPT
510
QLPGQNMKGS
520
RSSADSSRKH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003873 | 6-phosphofructo-2-kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004331 | fructose-2,6-bisphosphate 2-phosphatase activity |
| Biological Process | GO:0006003 | fructose 2,6-bisphosphate metabolic process |
| Biological Process | GO:0006000 | fructose metabolic process |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0006096 | glycolytic process |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.