Search Results
Overview
| Uniprot ID | Q16880 |
|---|---|
| Protein Name | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
| Gene Name | UGT8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 318 | ALGRLPQKVIWRFSG |
Function
Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity)
Protein Sequence
10
MKSYTPYFIL
20
LWSAVGIAKA
30
AKIIIVPPIM
40
FESHMYIFKT
50
LASALHERGH
60
HTVFLLSEGR
70
DIAPSNHYSL
80
QRYPGIFNST
90
TSDAFLQSKM
100
RNIFSGRLTA
110
IELFDILDHY
120
TKNCDLMVGN
130
HALIQGLKKE
140
KFDLLLVDPN
150
DMCGFVIAHL
160
LGVKYAVFST
170
GLWYPAEVGA
180
PAPLAYVPEF
190
NSLLTDRMNL
200
LQRMKNTGVY
210
LISRLGVSFL
220
VLPKYERIMQ
230
KYNLLPEKSM
240
YDLVHGSSLW
250
MLCTDVALEF
260
PRPTLPNVVY
270
VGGILTKPAS
280
PLPEDLQRWV
290
NGANEHGFVL
300
VSFGAGVKYL
310
SEDIANKLAG
320
ALGRLPQKVI
330
WRFSGPKPKN
340
LGNNTKLIEW
350
LPQNDLLGHS
360
KIKAFLSHGG
370
LNSIFETIYH
380
GVPVVGIPLF
390
GDHYDTMTRV
400
QAKGMGILLE
410
WKTVTEKELY
420
EALVKVINNP
430
SYRQRAQKLS
440
EIHKDQPGHP
450
VNRTIYWIDY
460
IIRHNGAHHL
470
RAAVHQISFC
480
QYFLLDIAFV
490
LLLGAALLYF
500
LLSWVTKFIY
510
RKIKSLWSRN
520
KHSTVNGHYH
530
NGILNGKYKR
540
NGHIKHEKKV
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0098553 | lumenal side of endoplasmic reticulum membrane |
| Molecular Function | GO:0003851 | N-acylsphingosine galactosyltransferase activity |
| Molecular Function | GO:0008489 | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0006682 | galactosylceramide biosynthetic process |
| Biological Process | GO:0006688 | glycosphingolipid biosynthetic process |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0030913 | paranodal junction assembly |
| Biological Process | GO:0007422 | peripheral nervous system development |
| Biological Process | GO:0002175 | protein localization to paranode region of axon |
| Biological Process | GO:0035902 | response to immobilization stress |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.