Search Results

Overview

Uniprot ID	Q16890
Protein Name	Tumor protein D53
Gene Name	TPD52L1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
123	NVGTAISKKFGDMSY
124	VGTAISKKFGDMSYS
68	ERHLVEIKQKLGMNL

Function

No function data available.

Protein Sequence

10 MEAQAQGLLE 20 TEPLQGTDED 30 AVASADFSSM 40 LSEEEKEELK 50 AELVQLEDEI 60 TTLRQVLSAK 70 ERHLVEIKQK 80 LGMNLMNELK 90 QNFSKSWHDM 100 QTTTAYKKTH 110 ETLSHAGQKA 120 TAAFSNVGTA 130 ISKKFGDMSY 140 SIRHSISMPA 150 MRNSPTFKSF 160 EERVETTVTS 170 LKTKVGGTNP 180 NGGSFEEVLS 190 STAHASAQSL 200 AGGSRRTKEE ELQC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Biological Process	GO:0046330	positive regulation of JNK cascade
Biological Process	GO:0043406	positive regulation of MAP kinase activity
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0042803	protein homodimerization activity
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.