Search Results

Overview

Uniprot IDQ17R98
Protein NameZinc finger protein 827
Gene NameZNF827
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
673 ETQMVKIKEEPMEVD

Function

As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861)

Protein Sequence

10 MPRRKQEQPK 20 RLPSHVSRQE 30 EAEGELSEGE 40 HWYGNSSETP 50 SEASYGEVQE 60 NYKLSLEDRI 70 QEQSTSPDTS 80 LGSTTPSSHT 90 LELVALDSEV 100 LRDSLQCQDH 110 LSPGVSSLCD 120 DDPGSNKPLS 130 SNLRRLLEAG 140 SLKLDAAATA 150 NGRVESPVNV 160 GSNLSFSPPS 170 HHAQQLSVLA 180 RKLAEKQEQN 190 DQYTPSNRFI 200 WNQGKWLPNS 210 TTTCSLSPDS 220 AILKLKAAAN 230 AVLQDKSLTR 240 TEETMRFESF 250 SSPFSSQSAS 260 STLAALSKKV 270 SERSLTPGQE 280 HPPPASSFLS 290 LASMTSSAAL 300 LKEVAARAAG 310 SLLAEKSSLL 320 PEDPLPPPPS 330 EKKPEKVTPP 340 PPPPPPPPPP 350 PPPQSLELLL 360 LPVPKGRVSK 370 PSNSASEEES 380 GKPFQCPICG 390 LVIKRKSYWK 400 RHMVIHTGLK 410 SHQCPLCPFR 420 CARKDNLKSH 430 MKVHQHQDRG 440 ETFQCQLCPF 450 TSSRHFSLKL 460 HMRCHQHFLR 470 TEAKVKEEIP 480 DPDVKGSPHL 490 SDSACLGQQR 500 EGGGTELVGT 510 MMTSNTPERT 520 SQGGAGVSPL 530 LVKEEPKEDN 540 GLPTSFTLNA 550 ADRPANHTKL 560 KDPSEYVANS 570 ASALFSQDIS 580 VKMASDFLMK 590 LSAANQKEPM 600 NLNFKVKEEP 610 KEGESLSTTL 620 PRSSYVFSPE 630 SEVSAPGVSE 640 DALKPQEGKG 650 SVLRRDVSVK 660 AASELLMKLS 670 AESYKETQMV 680 KIKEEPMEVD 690 IQDSHVSISP 700 SRNVGYSTLI 710 GREKTEPLQK 720 MPEGRVPPER 730 NLFSQDISVK 740 MASELLFQLS 750 EKVSKEHNHT 760 KENTIRTTTS 770 PFFSEDTFRQ 780 SPFTSNSKEL 790 LPSDSVLHGR 800 ISAPETEKIV 810 LEAGNGLPSW 820 KFNDQLFPCD 830 VCGKVFGRQQ 840 TLSRHLSLHT 850 EERKYKCHLC 860 PYAAKCRANL 870 NQHLTVHSVK 880 LVSTDTEDIV 890 SAVTSEGSDG 900 KKHPYYYSCH 910 VCGFETELNV 920 QFVSHMSLHV 930 DKEQWMFSIC 940 CTACDFVTME 950 EAEIKTHIGT 960 KHTGEDRKTP 970 SESNSPSSSS 980 LSALSDSANS 990 KDDSDGSQKN 1000 KGGNNLLVIS 1010 VMPGSQPSLN 1020 SEEKPEKGFE 1030 CVFCNFVCKT 1040 KNMFERHLQI 1050 HLITRMFECD 1060 VCHKFMKTPE 1070 QLLEHKKCHT 1080 VPTGGLNSGQ W

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0120325 NuRD complex binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0070200 establishment of protein localization to telomere
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:1904791 negative regulation of shelterin complex assembly
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0000723 telomere maintenance

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.