Overview
| Uniprot ID | Q17RY0 |
|---|
| Protein Name | Cytoplasmic polyadenylation element-binding protein 4 |
|---|
| Gene Name | CPEB4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 653 |
LQHGEIDKRVEVKPY |
Function
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity)
Protein Sequence
10
MGDYGFGVLV
20
QSNTGNKSAF
30
PVRFHPHLQP
40
PHHHQNATPS
50
PAAFINNNTA
60
ANGSSAGSAW
70
LFPAPATHNI
80
QDEILGSEKA
90
KSQQQEQQDP
100
LEKQQLSPSP
110
GQEAGILPET
120
EKAKSEENQG
130
DNSSENGNGK
140
EKIRIESPVL
150
TGFDYQEATG
160
LGTSTQPLTS
170
SASSLTGFSN
180
WSAAIAPSSS
190
TIINEDASFF
200
HQGGVPAASA
210
NNGALLFQNF
220
PHHVSPGFGG
230
SFSPQIGPLS
240
QHHPHHPHFQ
250
HHHSQHQQQR
260
RSPASPHPPP
270
FTHRNAAFNQ
280
LPHLANNLNK
290
PPSPWSSYQS
300
PSPTPSSSWS
310
PGGGGYGGWG
320
GSQGRDHRRG
330
LNGGITPLNS
340
ISPLKKNFAS
350
NHIQLQKYAR
360
PSSAFAPKSW
370
MEDSLNRADN
380
IFPFPDRPRT
390
FDMHSLESSL
400
IDIMRAENDT
410
IKGRLNYSYP
420
GSDSSLLINA
430
RTYGRRRGQS
440
SLFPMEDGFL
450
DDGRGDQPLH
460
SGLGSPHCFS
470
HQNGERVERY
480
SRKVFVGGLP
490
PDIDEDEITA
500
SFRRFGPLIV
510
DWPHKAESKS
520
YFPPKGYAFL
530
LFQDESSVQA
540
LIDACIEEDG
550
KLYLCVSSPT
560
IKDKPVQIRP
570
WNLSDSDFVM
580
DGSQPLDPRK
590
TIFVGGVPRP
600
LRAVELAMIM
610
DRLYGGVCYA
620
GIDTDPELKY
630
PKGAGRVAFS
640
NQQSYIAAIS
650
ARFVQLQHGE
660
IDKRVEVKPY
670
VLDDQLCDEC
680
QGARCGGKFA
690
PFFCANVTCL
700
QYYCEYCWAA
710
IHSRAGREFH
720
KPLVKEGGDR
PRHISFRWN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0000900 |
mRNA regulatory element binding translation repressor activity |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0008135 |
translation factor activity, RNA binding |
| Biological Process |
GO:0071230 |
cellular response to amino acid stimulus |
| Biological Process |
GO:0036294 |
cellular response to decreased oxygen levels |
| Biological Process |
GO:0042149 |
cellular response to glucose starvation |
| Biological Process |
GO:0035235 |
ionotropic glutamate receptor signaling pathway |
| Biological Process |
GO:2000766 |
negative regulation of cytoplasmic translation |
| Biological Process |
GO:0043524 |
negative regulation of neuron apoptotic process |
| Biological Process |
GO:0002931 |
response to ischemia |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0030426 |
growth cone |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0003730 |
mRNA 3'-UTR binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.