Search Results

Overview

Uniprot IDQ19S50
Protein NameSignal transducer and activator of transcription 3
Gene NameSTAT3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
294 LQQKVSYKGDPIVQH
348 TGVQFTTKVRLLVKF
365 LNYQLKIKVCIDKDS
370 KIKVCIDKDSGDVAA
383 AALRGSRKFNILGTN
87 QHNLRRIKQFLQSRY

Function

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (By similarity)

Protein Sequence

10 MAQWNQLQQL 20 DTRYLEQLHQ 30 LYSDSFPMEL 40 RQFLAPWIES 50 QDWAYAASKE 60 SHATLVFHNL 70 LGEIDQQYSR 80 FLQESNVLYQ 90 HNLRRIKQFL 100 QSRYLEKPME 110 IARIVARCLW 120 EESRLLQTAA 130 TAAQQGGQAN 140 HPTAAVVTEK 150 QQMLEQHLQD 160 VRKRVQDLEQ 170 KMKVVENLQD 180 DFDFNYKTLK 190 SQGDMQDLNG 200 NNQSVTRQKM 210 QQLEQMLTAL 220 DQMRRSIVSE 230 LAGLLSAMEY 240 VQKTLTDEEL 250 ADWKRRQQIA 260 CIGGPPNICL 270 DRLENWITSL 280 AESQLQTRQQ 290 IKKLEELQQK 300 VSYKGDPIVQ 310 HRPMLEERIV 320 ELFRNLMKSA 330 FVVERQPCMP 340 MHPDRPLVIK 350 TGVQFTTKVR 360 LLVKFPELNY 370 QLKIKVCIDK 380 DSGDVAALRG 390 SRKFNILGTN 400 TKVMNMEESN 410 NGSLSAEFKH 420 LTLREQRCGN 430 GGRANCDASL 440 IVTEELHLIT 450 FETEVYHQGL 460 KIDLETHSLP 470 VVVISNICQM 480 PNAWASILWY 490 NMLTNNPKNV 500 NFFTKPPIGT 510 WDQVAEVLSW 520 QFSSTTKRGL 530 SIEQLSTLAE 540 KLLGPGVNYS 550 GCQITWAKFC 560 KENMAGKGFS 570 FWVWLDNIID 580 LVKKYILALW 590 NEGYIMGFIS 600 KERERAILST 610 KPPGTFLLRF 620 SESSKEGGVT 630 FTWVEKDISG 640 KTQIQSVEPY 650 TKQQLNNMSF 660 AEIIMGYKIM 670 DATNILVSPL 680 VYLYPDIPKE 690 EAFGKYCRPE 700 SQEHPEADPG 710 SAAPYLKTKF 720 ICVTPTTCSN 730 TIDLPMSPRT 740 LDSLMQFGNN 750 GEGAEPSAGG 760 QFESLTFDME 770 LNSECATSPM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0001817 regulation of cytokine production
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0060259 regulation of feeding behavior
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0044321 response to leptin
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0072540 T-helper 17 cell lineage commitment
Biological Process GO:0072538 T-helper 17 type immune response
Biological Process GO:0001659 temperature homeostasis
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Biological Process GO:0048708 astrocyte differentiation
Biological Process GO:0007259 cell surface receptor signaling pathway via JAK-STAT
Biological Process GO:0097696 cell surface receptor signaling pathway via STAT
Biological Process GO:0044320 cellular response to leptin stimulus
Biological Process GO:0006952 defense response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042755 eating behavior
Biological Process GO:0097009 energy homeostasis
Biological Process GO:0001754 eye photoreceptor cell differentiation
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
Biological Process GO:0006954 inflammatory response
Biological Process GO:0070102 interleukin-6-mediated signaling pathway
Biological Process GO:0033210 leptin-mediated signaling pathway
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051240 positive regulation of multicellular organismal process
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0060019 radial glial cell differentiation
Biological Process GO:0051726 regulation of cell cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.