Search Results

Overview

Uniprot ID	Q1AAU6
Protein Name	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Gene Name	Asap1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
884	SSSKTANKFEGLSQQ

Function

Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity)

Protein Sequence

10 MRSSASRLSS 20 FSSRDSLWNR 30 MPDQISVSEF 40 IAETTEDYNS 50 PTTSSFTTRL 60 HNCRNTVTLL 70 EEALDQDRTA 80 LQKVKKSVKA 90 IYNSGQDHVQ 100 NEENYAQVLD 110 KFGSNFLSRD 120 NPDLGTAFVK 130 FSTLTKELST 140 LLKNLLQGLS 150 HNVIFTLDSL 160 LKGDLKGVKG 170 DLKKPFDKAW 180 KDYEMKFTKI 190 EKEKREHAKQ 200 HGMIRTEITG 210 AEIAEEMEKE 220 RRLFQLQMCE 230 YLIKVNEIKT 240 KKGVDLLQNL 250 IKYYHAQCNF 260 FQDGLKTADK 270 LKQYIEKLAA 280 DLYNIKQTQD 290 EEKKQLTALR 300 DLIKSSLQLD 310 PKEVGGLYVP 320 SRANSDSQSR 330 QGGYSMHQLQ 340 GNKEYGSEKK 350 GFLLKKSDGI 360 RKVWQRRKCA 370 VKNGILTISH 380 ATSNRQPAKL 390 NLLTCQVKPN 400 AEDKKSFDLI 410 SHNRTYHFQA 420 EDEQDYVAWI 430 SVLTNSKEEA 440 LTMAFRGEQS 450 TGENSLEDLT 460 KAIIEDVQRL 470 PGNDICCDCG 480 SSEPTWLSTN 490 LGILTCIECS 500 GIHREMGVHI 510 SRIQSLELDK 520 LGTSELLLAK 530 NVGNNSFNDI 540 MEANLPSPSP 550 KPTPSSDMTV 560 RKEYITAKYV 570 DHRFSRKTCA 580 SSSAKLNELL 590 EAIKSRDLLA 600 LIQVYAEGVE 610 LMEPLLEPGQ 620 ELGETALHLA 630 VRTADQTSLH 640 LVDFLVQNCG 650 NLDKQTSVGN 660 TVLHYCSMYG 670 KPECLKLLLR 680 SKPTVDIVNQ 690 NGETALDIAK 700 RLKATQCEDL 710 LSQAKSGKFN 720 PHVHVEYEWN 730 LRQDEMDESD 740 DDLDDKPSPI 750 KKERSPRPQS 760 FCHSSSISPQ 770 DKLALPGFST 780 PRDKQRLSYG 790 AFTNQIFVST 800 STDLPTSPTS 810 EAPPLPPRNA 820 GKGPTGPPST 830 LPLGTQTSSG 840 SSTLSKKRSP 850 PPPPGHKRTL 860 SDPPSPLPHG 870 PPNKGAIPWG 880 NDVGPSSSSK 890 TANKFEGLSQ 900 QASTSSAKTA 910 LGPRVLPKLP 920 QKVALRKTET 930 SHHLSLDRAN 940 IPPETFQKSS 950 QLSELPQKPP 960 LGDLPPKPME 970 LAPKPQIGEL 980 PPKPGELPPK 990 PQLGDLPPKP 1000 QLSDLPPKPQ 1010 MKDLPPKPQL 1020 GDLLAKSQAS 1030 DLSAKVQPPS 1040 EVTQRSHTGD 1050 LSPNVQSRDA 1060 IQKQASEDSN 1070 DLTPTLPETP 1080 VPLPRKINTG 1090 KNKVRRVKTI 1100 YDCQADNDDE 1110 LTFIEGEVII 1120 VTGEEDQEWW 1130 IGHIEGQPER 1140 KGVFPVSFVH ILSD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031253	cell projection membrane
Cellular Component	GO:0034451	centriolar satellite
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0002102	podosome
Cellular Component	GO:0032588	trans-Golgi network membrane
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
Molecular Function	GO:0001786	phosphatidylserine binding
Molecular Function	GO:0017124	SH3 domain binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0060271	cilium assembly
Biological Process	GO:0061000	negative regulation of dendritic spine development
Biological Process	GO:1903527	positive regulation of membrane tubulation
Biological Process	GO:0071803	positive regulation of podosome assembly
Biological Process	GO:0061512	protein localization to cilium
Biological Process	GO:0099175	regulation of postsynapse organization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.