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Overview

Uniprot ID	Q1KQ07
Protein Name	Signal transducer and activator of transcription
Gene Name	Stat6
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
374	KIKRCERKGTESVTE

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling

Protein Sequence

10 MSLWSLVSKM 20 SPEKLQRLYV 30 DFPQHLRHLL 40 AEWLENQPWE 50 FLVGSDAFCY 60 NMASALLSAT 70 VQRLQASAGE 80 QGKGSSLLQH 90 ISTLESIYQR 100 DPLKLVATIR 110 QILQGEKKAV 120 IEEFHHLPGP 130 FHRKQEELKF 140 TTALGRLQHR 150 VRETRILRES 160 LQQGTKTAQV 170 SLKNLIDPPA 180 NGTGPSEDLA 190 TMLQGTVGDL 200 EATQALVLKR 210 IQIWKRQQQL 220 AGNGTPFEES 230 LAGLQERCES 240 LVEIYSQLQQ 250 EIGAASGELE 260 PKTRASLISR 270 LDEVLRTLVT 280 SSFLVEKQPP 290 QVLKTQTKFQ 300 AGVRFLLGLQ 310 FLGTSAKPPL 320 VRADMVTEKQ 330 ARELSLPQGS 340 GAGVESTGEI 350 MNNTVPLENS 360 VPGNCCSALF 370 KNLLLKKIKR 380 CERKGTESVT 390 EEKCAVLFST 400 SFMLGPNKHL 410 IQLQALSLPL 420 VVIVHGNQDN 430 NAKATILWDN 440 AFSEMDRVPF 450 VVAERVPWEK 460 MCETLNLKFM 470 AEVGTSRGLL 480 PEHFLFLAQK 490 IFNDNSLSIE 500 AFQHRCVSWS 510 QFNKEILLGR 520 GFTFWQWFDG 530 VLDLTKRCLR 540 SYWSDRLIIG 550 FISKQYVTSL 560 LLNEPDGTFL 570 LRFSDSEIGG 580 ITIAHVIRGQ 590 DGSSQIENIQ 600 PFSAKDLSIR 610 SLGDRIRDLA 620 QLKNLYPKKP 630 KDEAFRSHYK 640 PEQMGKDGRG 650 YVSTTIKMTV 660 ERDQPLPTPE 670 PQMPAMVAPY 680 DLGMAPDASM 690 QLSSDMVYPP 700 QSHSIHSFQS 710 IPLEESMSVL 720 PPFQEPHLQM 730 PPTMSQISMP 740 FDQPHPQGLL 750 QCQSQEHAVS 760 SPEPLLCSDV 770 TMAEDSCLTQ 780 PVQGFPQGTW 790 VSEGMYPPLM 800 PPTEQDLTKL 810 LLEGQGEGGG 820 SIGTQPLLQP 830 SSYGQSGISM 840 SHLDLRTNPS W

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0048732	gland development
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.