Search Results
Overview
| Uniprot ID | Q1RP74 |
|---|---|
| Protein Name | Tubulin-folding cofactor B |
| Gene Name | Tbcb |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | EDVSKVEKYEISPEA |
| 129 | RSFMKRSKLGPYNEE |
Function
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0035371 | microtubule plus-end |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0007023 | post-chaperonin tubulin folding pathway |
| Biological Process | GO:0007021 | tubulin complex assembly |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.