Search Results
Overview
| Uniprot ID | Q1WIM2 |
|---|---|
| Protein Name | Cell adhesion molecule 2 |
| Gene Name | Cadm2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | IKDVKYLKEEDANRK |
| 396 | GRYLARHKGTYLTNE |
Function
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity)
Protein Sequence
10
MIWKRSAVLR
20
FYSVCGLLLL
30
GSQGQFPLTQ
40
NVTVVEGGTA
50
ILTCRVDQND
60
NTSLQWSNPA
70
QQTLYFDDKK
80
ALRDNRIELV
90
RASWHELSIS
100
VSDVSLSDEG
110
QYTCSLFTMP
120
VKTSKAYLTV
130
LGVPEKPQIS
140
GFSSPVMEGD
150
LMQLTCKTSG
160
SKPAADIRWF
170
KNDKEIKDVK
180
YLKEEDANRK
190
TFTVSSTLDF
200
RVDRSDDGVA
210
VICRVDHESL
220
NATPQVAMQV
230
LEIHYTPSVK
240
IIPSTPFPQE
250
GQALTLTCES
260
KGKPLPEPVL
270
WTKDGAELPD
280
PDRMVVSGRE
290
LNILFLNKTD
300
NGTYRCEATN
310
TIGQSSAEYV
320
LIVHDVPNTL
330
LPTTIIPSLT
340
TAPVTTTVAI
350
TTSPSTSASS
360
SSRRDPNSLA
370
GQNGPDHALI
380
GGIVAVVVFV
390
TLCSIFLLGR
400
YLARHKGTYL
410
TNEAKGAEDA
420
PDADTAIINA
430
EGSQVNAEEK
KEYFI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0032809 | neuronal cell body membrane |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Biological Process | GO:0007156 | homophilic cell-cell adhesion |
| Biological Process | GO:0099560 | synaptic membrane adhesion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.