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Overview

Uniprot IDQ28832
Protein NameLow-density lipoprotein receptor
Gene NameLDLR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
254 CEGPNKFKCQSGECI

Function

Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization

Protein Sequence

10 FQCQDGKCIS 20 YKWICDGNTE 30 CKDGSDESLE 40 TCMSVTCKIG 50 DFSCGGRVNR 60 CIPESWRCDG 70 QQDCENGSDE 80 EGCSPKTCSQ 90 DEFRCQDGKC 100 IAPKFVCDSD 110 RDCLDGSDEA 120 SCPTPTCGPA 130 SFQCNSSTCI 140 PELWACDGDP 150 DCEDGSDEWP 160 QHCRSHSSSL 170 PERSNNPCSA 180 LEFHCHSGEC 190 IHSSWRCDGD 200 TDCKDKSDEE 210 NCDVATCRPD 220 EFQCSDGTCI 230 HGSRQCDREY 240 DCKDMSDEQG 250 CVNATLCEGP 260 NKFKCQSGEC 270 ISLDKVCNSV 280 RDCRDWSDEP 290 LKECGTNECL 300 DNKGGCSHIC 310 NDLKIGYECL 320 CPEGFQLVDK 330 HRCEDIDECQ 340 DPDACSQICV 350 NLEGSYKCQC 360 EEGFQLEPLT 370 KACKAIGTIA 380 YLFFTNRHEV 390 RKMTLDRSEY 400 TSLIPNLKNV 410 VALDTEVASN 420 RIYWSDLSQR 430 KIYSTQIDRA 440 PSFSSYDTII 450 GEDLQAPDGL 460 AVDWIHSNIY 470 WTDSILGTVS 480 VADTKGVKRK 490 TLFQEKGSKP 500 RAIVVDPVHG 510 FMYWTDWGTP 520 AKIKKGGLNG 530 VDVYSLVTED 540 IQWPNGITLD 550 LSGGRLYWVD 560 SKLHSISSID 570 VNGGNRKTVL 580 EDKTKLAHPF 590 SLAIFEDKVF 600 WTDIINEAIF 610 SANRLTGSDI 620 HLMAENLLSP 630 EDIVLFHNLT 640 QPRGVNWCER 650 TALQNGGCQY 660 LCLPAPQINP 670 RSPKFTCACP 680 DGMLLAKDMR 690 SCLTETEPAG 700 TTQGPSMVNS 710 TAVGPKHTAS 720 SELTTAESVT 730 MSQHALGDVA 740 GRGVTEKPQS 750 VGALYIVLPI 760 ALLILLFFGT 770 FLLWKNWRLK 780 SINSINFDNP 790 VYQKTTEDEV 800 HICRSQDGYT 810 YPSRQMVSLE D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005770 late endosome
Cellular Component GO:0034362 low-density lipoprotein particle
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0071813 lipoprotein particle binding
Molecular Function GO:0005041 low-density lipoprotein particle receptor activity
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
Biological Process GO:0045056 transcytosis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.