Overview
| Uniprot ID | Q29048 |
|---|
| Protein Name | V-type proton ATPase catalytic subunit A |
|---|
| Gene Name | ATP6V1A |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 220 |
QVRPVTEKLPANHPL |
Function
Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment. The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity
Protein Sequence
10
MDFSKLPKIL
20
DEDKESTFGY
30
VHGVSGPVVT
40
ACDMAGAAMY
50
ELVRVGHSEL
60
VGEIIRLEGD
70
MATIQVYEET
80
SGVSVGDPVL
90
RTGKPLSVEL
100
GPGIMGAIFD
110
GIQRPLSDIS
120
SQTQSIYIPR
130
GVNVSALSRD
140
VKWEFTPSKN
150
LRVGSHITGG
160
DIYGIVNENS
170
LIKHRIMLPP
180
RNRGTVTYIA
190
PPGNYDTSDV
200
VLELEFEGVK
210
EKFSMVQVWP
220
VRQVRPVTEK
230
LPANHPLLTG
240
QRVLDALFPC
250
VQGGTTAIPG
260
AFGCGKTVIS
270
QSLSKYSNSD
280
VIIYVGCGER
290
VNEMSEVLRD
300
FPELTMEVDG
310
KVESIMKRTA
320
LVANTSNMPV
330
AAREASIYTG
340
ITLSEYFRDM
350
GYHVSMMANS
360
TSRWAEALRE
370
ISGRLAEMPA
380
DSGYPAYLGA
390
RLASFYERAG
400
RVKCLGNPER
410
EGSVTIVGAV
420
SPPGGDFSDP
430
VTSATLGIVQ
440
VFWGLDKKLA
450
QRKHFPSVNW
460
LISYSKYMRA
470
LDEYYDKHFT
480
EFVPLRTKAK
490
EILQEEEDLA
500
EIVQLVGKAS
510
LAETDKITLE
520
VAKLIKDDFL
530
QQNGYTPYDR
540
FCPFYKTVGM
550
LSNMIAFYDL
560
ARRAVETTAQ
570
SDNKITWSII
580
REHMGEILYK
590
LSSMKFKDPV
600
KDGEAKIKAD
610
YAQLLEDVQN
AFRSLED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030665 |
clathrin-coated vesicle membrane |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030133 |
transport vesicle |
| Cellular Component |
GO:0000221 |
vacuolar proton-transporting V-type ATPase, V1 domain |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
| Biological Process |
GO:0046034 |
ATP metabolic process |
| Biological Process |
GO:0036295 |
cellular response to increased oxygen levels |
| Biological Process |
GO:0006879 |
intracellular iron ion homeostasis |
| Biological Process |
GO:1902600 |
proton transmembrane transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.