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Overview

Uniprot IDQ29052
Protein NameInter-alpha-trypsin inhibitor heavy chain H1
Gene NameITIH1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
53 RSLKVNCKVTSRFAH

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MDGTMGLQGL 20 LCLCLASHLA 30 LQAMPTQGSP 40 TDSTKGNKAV 50 NGVVIRSLKV 60 NCKVTSRFAH 70 YVVTSQVVNN 80 TNKPKEVAFD 90 VEIPKTAFIS 100 DFAITADENT 110 FVGDIKDKVT 120 AWKQYRKAAI 130 SGENSGLVRA 140 SGRTMEQFTI 150 HVTIGPRSKA 160 TFQLTYEEVL 170 RRKLTQYDIV 180 IKVKPKQLVQ 190 HFEIDVDIFE 200 PQGISKLDAQ 210 ASFLSKEAAA 220 QLIKKSFSGK 230 KGHVLFRPTV 240 GQQQSCSTCS 250 TTLLNGDFKV 260 TYDVNREKLC 270 DLLVANNYFA 280 HFFAPQNLTK 290 LNKNVVFVID 300 ISSSMEGQKV 310 KQTKEALLKI 320 LSDLKPGDYF 330 DLVLFGSAVQ 340 SWRGSLVQAS 350 TANLDAARSY 360 VRQFSLAGST 370 NLNGGLLRGI 380 EILNKAQGSL 390 PEFSNRASIL 400 IMLTDGEPTE 410 GVTDRSQILK 420 NVRDAIRGRF 430 PLYNLGFGHD 440 VEWNFLEVRA 450 LENNGRAQRI 460 YEDHDSAQQL 470 QGFYDQVANP 480 LLKDVELQYP 490 ADAVLALTQH 500 RHKQYYEGSE 510 ITVAGRIADN 520 KLSSFKADVQ 530 ASGDQGFKTT 540 CLVDEEEMKK 550 LLQERGHMLE 560 NYVERLWAYL 570 TIQELLAKRM 580 KLEWAEKASV 590 SAKALQMSLD 600 YQFVTPLTSM 610 TIRGMADKDG 620 LEPVIDKPLE 630 DSQPLEMLGP 640 RRKFVLSASQ 650 PSPTHPSSSI 660 QKLPDRVTGV 670 DTDPHFIIRV 680 PQKEDTLCFN 690 INEEPGVVLS 700 LVQDPDTGFS 710 VNGQLIGNEA 720 RCPGKHEGTY 730 FGRLGIANPA 740 TGFQLEVTPQ 750 NITLNPGSGG 760 PVFSWRDQAS 770 LRQDEVVVTI 780 NRKRNLGVVR 790 EDGGTFEVVL 800 HRLWKGSAIH 810 QDFLGFYVLD 820 SHRMSARTHG 830 LLAQFFHPFD 840 YKVSDIHPGS 850 DPTKTDATMV 860 VKNRQLTVTR 870 GLQKDYSKDP 880 RHGLKVTCWF 890 IHNNGDGLID 900 GVHTDYIVPD IF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Biological Process GO:0030212 hyaluronan metabolic process
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0006953 acute-phase response

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.