Overview
| Uniprot ID | Q29073 |
|---|
| Protein Name | Prostaglandin reductase 1 |
|---|
| Gene Name | PTGR1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 168 |
IAKLKGCKVVGAAGS |
| 178 |
GAAGSDEKVACLKKY |
Function
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:10837478, PubMed:11688989, PubMed:8576264, PubMed:9461497). Preferentially uses NADPH over NADH as cofactor (PubMed:9461497). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:11688989, PubMed:9461497). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:8394361, PubMed:8576264). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4 and may promote neutrophil recruitment at the inflammatory site (PubMed:10837478, PubMed:11688989). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity)
Protein Sequence
10
MVRAKSWTLK
20
KHFVGYPTPS
30
NFELKTVELP
40
PLKNGEVLLE
50
ALFLTVDPYM
60
RIAARKLKEG
70
DMMMGEQVAR
80
VIESKNAAFP
90
TGTIVVALLG
100
WTTHSISDGK
110
NLERLLAEWP
120
DTLPLSLTLG
130
TVGMPGLTAY
140
FGLLDICGLK
150
GGETVMVNAA
160
AGAVGSVVGQ
170
IAKLKGCKVV
180
GAAGSDEKVA
190
CLKKYGFDVA
200
FNYKTIESLE
210
ETLKKASPEG
220
YDCYFDNVGG
230
EFSNAVTSQM
240
KKFGRIAICG
250
AISTYNRTGP
260
PPPGPPPEVV
270
IYNELCFQGF
280
IVTRWQGEVR
290
QKALRDLLKW
300
VSEGKIQYHE
310
HITEGFENMP
320
AAFMGMLKGE
NLGKAIVKA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0036185 |
13-lipoxin reductase activity |
| Molecular Function |
GO:0047522 |
15-oxoprostaglandin 13-reductase [NAD(P)+] activity |
| Molecular Function |
GO:0035798 |
2-alkenal reductase (NADPH) activity |
| Molecular Function |
GO:0097257 |
leukotriene B4 12-hydroxy dehydrogenase activity |
| Biological Process |
GO:0036102 |
leukotriene B4 metabolic process |
| Biological Process |
GO:2001302 |
lipoxin A4 metabolic process |
| Biological Process |
GO:0006693 |
prostaglandin metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.