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Overview

Uniprot IDQ29092
Protein NameEndoplasmin
Gene NameHSP90B1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
114 NASDALDKIRLISLT
142 KIKCDKEKNLLHVTD
161 MTREELVKNLGTIAK
168 KNLGTIAKSGTSEFL
348 PIWQRPSKEVEDDEY
356 EVEDDEYKAFYKSFS
404 LFDEYGSKKSDYIKL
410 SKKSDYIKLYVRRVF
455 RETLQQHKLLKVIRK
467 IRKKLVRKTLDMIKK
473 RKTLDMIKKIADEKY
479 IKKIADEKYNDTFWK
493 KEFGTNIKLGVIEDH
547 FMAGSSRKEAESSPF
593 KRFQNVAKEGVKFDE
597 NVAKEGVKFDESEKS
603 VKFDESEKSKENREA
633 ALKDKIEKAVVSQRL
663 GNMERIMKAQAYQTG
671 AQAYQTGKDISTNYY
682 TNYYASQKKTFEINP
683 NYYASQKKTFEINPR
733 GYLLPDTKAYGDRIE
75 ELREKSEKFAFQAEV
95 LIINSLYKNKEIFLR
97 INSLYKNKEIFLREL

Function

ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity)

Protein Sequence

10 MRALWVLGLC 20 CVLLTFGSVR 30 AEDEVDVDGT 40 VEEDLGKSRE 50 GSRTDDEVVQ 60 REEEAIQLDG 70 LNASQIRELR 80 EKSEKFAFQA 90 EVNRMMKLII 100 NSLYKNKEIF 110 LRELISNASD 120 ALDKIRLISL 130 TDENALAGNE 140 ELTVKIKCDK 150 EKNLLHVTDT 160 GVGMTREELV 170 KNLGTIAKSG 180 TSEFLNKMAE 190 AQEDGQSTSE 200 LIGQFGVGFY 210 SAFLVADKVI 220 VTSKHNNDTQ 230 HIWESDSNEF 240 SVIADPRGNT 250 LGRGTTITLV 260 LKEEASDYLE 270 LDTIKNLVKK 280 YSQFINFPIY 290 VWSSKTETVE 300 EPMEEEEAAK 310 EEKEESDDEA 320 AVEEEEEEKK 330 PKTKKVEKTV 340 WDWELMNDIK 350 PIWQRPSKEV 360 EDDEYKAFYK 370 SFSKESDDPM 380 AYIHFTAEGE 390 VTFKSILFVP 400 TSAPRGLFDE 410 YGSKKSDYIK 420 LYVRRVFITD 430 DFHDMMPKYL 440 NFVKGVVDSD 450 DLPLNVSRET 460 LQQHKLLKVI 470 RKKLVRKTLD 480 MIKKIADEKY 490 NDTFWKEFGT 500 NIKLGVIEDH 510 SNRTRLAKLL 520 RFQSSHHPSD 530 ITSLDQYVER 540 MKEKQDKIYF 550 MAGSSRKEAE 560 SSPFVERLLK 570 KGYEVIYLTE 580 PVDEYCIQAL 590 PEFDGKRFQN 600 VAKEGVKFDE 610 SEKSKENREA 620 VEKEFEPLLN 630 WMKDKALKDK 640 IEKAVVSQRL 650 TESPCALVAS 660 QYGWSGNMER 670 IMKAQAYQTG 680 KDISTNYYAS 690 QKKTFEINPR 700 HPLIRDMLRR 710 VKEDEDDKTV 720 SDLAVVLFET 730 ATLRSGYLLP 740 DTKAYGDRIE 750 RMLRLSLNID 760 PDAKVEEEPE 770 EEPEETTEDT 780 TEDTEQDDDE 790 EMDAGADEEE 800 QETSETSTAE KDEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0042470 melanosome
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0033018 sarcoplasmic reticulum lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140662 ATP-dependent protein folding chaperone
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0006457 protein folding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.