Overview
| Uniprot ID | Q29101 |
|---|
| Protein Name | Gap junction alpha-1 protein |
|---|
| Gene Name | GJA1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 136 |
QIEIKKFKYGIEEHG |
| 144 |
YGIEEHGKVKMRGGL |
| 258 |
TGPLSPSKDCGSPKY |
| 303 |
SSCRNYNKQASEQNW |
Function
Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (By similarity). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in the conductive system of ventricular myocardium and heart morphogenesis. May play a role in cell growth inhibition through the regulation of NOV expression and localization (By similarity). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity)
Protein Sequence
10
MGDWSALGKL
20
LDKVQAYSTA
30
GGKVWLSVLF
40
IFRILLLGTA
50
VESAWGDEQS
60
AFRCNTQQPG
70
CENVCYDKSF
80
PISHVRFWVL
90
QIIFVSVPTL
100
LYLAHVFYVM
110
RKEEKLNKKE
120
EELKVAQTDG
130
VNVEMHLKQI
140
EIKKFKYGIE
150
EHGKVKMRGG
160
LLRTYIISIL
170
FKSVFEVAFL
180
LIQWYIYGFS
190
LSAVYTCKRD
200
PCPHQVDCFL
210
SRPTEKTIFI
220
IFMLVVSLVS
230
LALNIIELFY
240
AFFKGVKDRV
250
KGKSDPYHAT
260
TGPLSPSKDC
270
GSPKYAYFNG
280
CSSPTAPLSP
290
MSPPGYKLVT
300
GDRNNSSCRN
310
YNKQASEQNW
320
ANYSAEQNRM
330
GQAGSTISNS
340
HAQPFDFPDD
350
NQNSKKLDAG
360
HELQPLAIVD
370
QRPSSRASSR
380
ASSRPRPDDL
EI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0005922 |
connexin complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005921 |
gap junction |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0014704 |
intercalated disc |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005243 |
gap junction channel activity |
| Molecular Function |
GO:0055077 |
gap junction hemi-channel activity |
| Molecular Function |
GO:0015631 |
tubulin binding |
| Biological Process |
GO:0060348 |
bone development |
| Biological Process |
GO:0046849 |
bone remodeling |
| Biological Process |
GO:0010644 |
cell communication by electrical coupling |
| Biological Process |
GO:0007267 |
cell-cell signaling |
| Biological Process |
GO:0036120 |
cellular response to platelet-derived growth factor stimulus |
| Biological Process |
GO:0007507 |
heart development |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0099111 |
microtubule-based transport |
| Biological Process |
GO:0030308 |
negative regulation of cell growth |
| Biological Process |
GO:0071673 |
positive regulation of smooth muscle cell chemotaxis |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0002931 |
response to ischemia |
| Biological Process |
GO:0009611 |
response to wounding |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.