Search Results

Overview

Uniprot IDQ29122
Protein NameUnconventional myosin-VI
Gene NameMYO6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1059 KYDLSKWKYAELRDT
113 IYSSETIKSYQGKSL
289 FANKETDKQILQNRK
409 GAKGTVIKVPLKVEQ
491 FFNERILKEEQELYQ
565 LSIPRKSKLAIHRNI
898 MTREQIQKEYDALVK

Function

Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (PubMed:15944696). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (PubMed:16917816). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (By similarity). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). May act as a regulator of F-actin dynamics (PubMed:7929586). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (By similarity)

Protein Sequence

10 MEDGKPVWAP 20 HPTDGFQVGN 30 IVDIGPDSLT 40 IEPLNQKGKT 50 FLALINQVFP 60 AEEDSKKDVE 70 DNCSLMYLNE 80 ATLLHNIKVR 90 YSKDRIYTYV 100 ANILIAVNPY 110 FDIPKIYSSE 120 TIKSYQGKSL 130 GTMPPHVFAI 140 ADKAFRDMKV 150 LKLSQSIIVS 160 GESGAGKTEN 170 TKFVLRYLTE 180 SYGTGQDIDD 190 RIVEANPLLE 200 AFGNAKTVRN 210 NNSSRFGKFV 220 EIHFNEKSSV 230 VGGFVSHYLL 240 EKSRICVQGK 250 EERNYHIFYR 260 LCAGASEDIR 270 ERLHLSSPDN 280 FRYLNRGCTR 290 YFANKETDKQ 300 ILQNRKSPEY 310 LKAGSLKDPL 320 LDDHGDFIRM 330 CTAMKKIGLD 340 DEEKLDLFRV 350 VAGVLHLGNI 360 DFEEAGSTSG 370 GCNLKNKSTQ 380 ALEYCAEKLL 390 GLDQDDLRVS 400 LTTRVMLTTA 410 GGAKGTVIKV 420 PLKVEQANNA 430 RDALAKTVYS 440 HLFDHVVNRV 450 NQCFPFETSS 460 YFIGVLDIAG 470 FEYFEHNSFE 480 QFCINYCNEK 490 LQQFFNERIL 500 KEEQELYQKE 510 GLGVNEVHYV 520 DNQDCIDLIE 530 ARLVGILDIL 540 DEENRLPQPS 550 DQHFTSAGHQ 560 KHKDHFRLSI 570 PRKSKLAIHR 580 NIAYDEGFII 590 RHFAGAVCYE 600 TTQFVEKNND 610 ALHMSLESLI 620 CESRDKFIRE 630 LFESSTNNNK 640 DTKQKAGKLS 650 FISVGNKFKT 660 QLNLLLDKLR 670 STGASFIRCI 680 KPNLKMTSHH 690 FEGAQILSQL 700 QCSGMVSVLD 710 LMQGGFPSRA 720 SFHEVYNMYK 730 KSLPDKLARL 740 DPRLFCKALF 750 KALGLNEIDY 760 KFGLTKVFFR 770 PGKFAEFDQI 780 MKSDPDHLAE 790 LVKRVNHWLI 800 CSRWKKVQWC 810 SLSVIKLKNK 820 IKYRAEACIK 830 MQKTIRMWLC 840 KRRHKPRIDG 850 LVKVGTLKKR 860 LDKFNEVVSA 870 LKDGKQEMSK 880 QVKDLEISID 890 ALMAKIKSTM 900 MTREQIQKEY 910 DALVKSSAVL 920 LSALQKKKQQ 930 EEEAERLRRI 940 QEEMEKERKR 950 REEDEQRRRK 960 EEEERRMKLE 970 MEAKRKQEEE 980 ERKKREDDEK 990 RIQAEVEAQL 1000 ARQREEESQQ 1010 QAVLEQERRD 1020 RELALRIAQS 1030 EAELISDEAQ 1040 ADPGLRRGPA 1050 VQATKAAAGT 1060 KKYDLSKWKY 1070 AELRDTINTS 1080 CDIELLAACR 1090 EEFHRRLKVY 1100 HAWKSKNKKR 1110 NTETEQRAPK 1120 SVTDYAQQNP 1130 AVQLPARQQE 1140 IEMNRQQRFF 1150 RIPFIRSADQ 1160 YKDPQNKKKG 1170 WWYAHFDGPW 1180 IARQMELHPD 1190 KPPILLVAGK 1200 DDMEMCELNL 1210 EETGLTRKRG 1220 AEILPRQFEE 1230 IWERCGGIQY 1240 LQNAIESRQA 1250 RPTYATAMLQ NLLK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005884 actin filament
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0030175 filopodium
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005902 microvillus
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001726 ruffle
Cellular Component GO:0032587 ruffle membrane
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0003774 cytoskeletal motor activity
Molecular Function GO:0000146 microfilament motor activity
Biological Process GO:0007015 actin filament organization
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0030330 DNA damage response, signal transduction by p53 class mediator
Biological Process GO:0006897 endocytosis
Biological Process GO:0042491 inner ear auditory receptor cell differentiation
Biological Process GO:0042472 inner ear morphogenesis
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0051046 regulation of secretion
Biological Process GO:0007605 sensory perception of sound

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.