Overview
| Uniprot ID | Q29175 |
|---|
| Protein Name | Zinc transporter SLC39A7 |
|---|
| Gene Name | SLC39A7 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 276 |
VECPSKEKQSSEEEE |
Function
Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation on residues, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling (By similarity). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts. Mediates Zn(2+)-induced ferroptosis (By similarity)
Protein Sequence
10
MARGLGAPHR
20
VAVGLLTWAA
30
LGLLVAGHGG
40
HGDLYEDLQE
50
DLHGHSHRHS
60
HEDFHHGHSH
70
AHGHGHTHES
80
IWHGHTHGHD
90
HGHSHEDLHH
100
GHIHGDSHES
110
LYHPGHGHDH
120
EHSHGGYGES
130
GAPGIKQDLD
140
TVTLWAYALG
150
ATVLISAAPF
160
FVLFLIPVES
170
NSPRHRSLLQ
180
ILLSFASGGL
190
LGDAFLHLIP
200
HALEPHSHHP
210
LEQPGHGHSH
220
SGQGPILSVG
230
LWVLSGIVAF
240
LVVEKFVRHV
250
KGGHEHSHGH
260
GHAHGHTHGG
270
DSPFEDILVE
280
CPSKEKQSSE
290
EEEKEAGASR
300
KRRGGSTRPK
310
DGPVRPQHSG
320
EEKAGSDLRV
330
SGYLNLAADL
340
AHNFTDGLAI
350
GASFRGGRGL
360
GILTTMTVLL
370
HEVPHEVGDF
380
AILVQSGCSK
390
KQAMRLQLLT
400
AVGALAGTAF
410
ALLTEGGAAG
420
SEVAGGTGPG
430
WVLPFTAGDQ
440
AATQASPRST
450
SLPPVGEEDF
460
REDPGPRQKG
470
QQEKSGINVN
CVS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Molecular Function |
GO:0005385 |
zinc ion transmembrane transporter activity |
| Biological Process |
GO:0030183 |
B cell differentiation |
| Biological Process |
GO:0006882 |
intracellular zinc ion homeostasis |
| Biological Process |
GO:0110075 |
regulation of ferroptosis |
| Biological Process |
GO:0098773 |
skin epidermis development |
| Biological Process |
GO:0071577 |
zinc ion transmembrane transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.