Search Results
Overview
| Uniprot ID | Q29221 |
|---|---|
| Protein Name | F-actin-capping protein subunit alpha-2 |
| Gene Name | CAPZA2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | FKFDHLRKEATDPRP |
| 133 | TALRAYVKEHYPNGV |
| 146 | GVCTVYGKKIDGQQT |
| 147 | VCTVYGKKIDGQQTI |
| 268 | QLPVTRTKIDWNKIL |
| 91 | NGKFLDPKNRICFKF |
| 97 | PKNRICFKFDHLRKE |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity)
Protein Sequence
10
MADLEEQLSD
20
EEKVRIAAKF
30
IIHAPPGEFN
40
EVFNDVRLLL
50
NNDNLLREGA
60
AHAFAQYNLD
70
QFTPVKIEGY
80
EDQVLITEHG
90
DLGNGKFLDP
100
KNRICFKFDH
110
LRKEATDPRP
120
YEAENAVESW
130
RTSVETALRA
140
YVKEHYPNGV
150
CTVYGKKIDG
160
QQTIIACIES
170
HQFQAKNFWN
180
GRWRSEWKFT
190
ITPSTTQVVG
200
ILKIQVHYYE
210
DGNVQLVSHK
220
DIQDSLTVSN
230
EVQTAKEFIK
240
IVEAAENEYQ
250
TAISENYQTM
260
SDTTFKALRR
270
QLPVTRTKID
280
WNKILSYKIG
KEMQNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.