Search Results
Overview
| Uniprot ID | Q29228 |
|---|---|
| Protein Name | 4-trimethylaminobutyraldehyde dehydrogenase |
| Gene Name | ALDH9A1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 249 | EMSAKGIKPVTLELG |
| 298 | GTRVFVQKEILDKFT |
| 310 | KFTEEVVKQTQRIKI |
| 316 | VKQTQRIKIGDPLLE |
| 344 | ERILGFVKVAKEQGA |
| 59 | NLAVQDAKAAFKIWS |
Function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines
Protein Sequence
10
MSTGTFIVSQ
20
PLNYRGGARV
30
DPVDASGTEK
40
AFEPATGRVI
50
ATFTCSGEKE
60
VNLAVQDAKA
70
AFKIWSQKSG
80
MERCRILLEA
90
ARIIRERKEE
100
IATMETINNG
110
KSIFEARLDV
120
DISWQCLEYY
130
AGLAGSMAGE
140
HIQLPGGSFG
150
YTRREPLGVC
160
VGIGAWNYPF
170
QIACWKSAPA
180
LACGNAMIFK
190
PSPFTPLSVL
200
LLAEIYTEAG
210
VPPGLFNVVQ
220
GGATTGQLLC
230
QHRDVAKISF
240
TGSVPTGSKI
250
MEMSAKGIKP
260
VTLELGGKSP
270
LIIFSDCDMG
280
NAVKGALMAN
290
FLTQGEVCCN
300
GTRVFVQKEI
310
LDKFTEEVVK
320
QTQRIKIGDP
330
LLEDTRMGPL
340
INRPHLERIL
350
GFVKVAKEQG
360
AKVLCGGDLY
370
VPEDPKLKEG
380
YYMRPCVLTN
390
CRDDMTCVKE
400
EIFGPVMSIL
410
SFDTEAEVVE
420
RANDTTFGLA
430
AGVFTRDIQR
440
AHRVVAELQA
450
GMCFINNYNV
460
SPVELPFGGY
470
KKSGFGRENG
480
RVTIEYYSQL
490
KTVCVEMGDV
ESVF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0047105 | 4-trimethylammoniobutyraldehyde dehydrogenase activity |
| Molecular Function | GO:0140087 | acetaldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004029 | aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0019145 | aminobutyraldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0018467 | formaldehyde dehydrogenase (NAD+) activity |
| Biological Process | GO:0006081 | aldehyde metabolic process |
| Biological Process | GO:0045329 | carnitine biosynthetic process |
| Biological Process | GO:0051289 | protein homotetramerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.