Overview
| Uniprot ID | Q29548 |
|---|
| Protein Name | Beta-hexosaminidase subunit beta |
|---|
| Gene Name | HEXB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 374 |
NMISAMKKRPIVWQE |
Function
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity)
Protein Sequence
10
MEVLPGLLRL
20
LAALVVAERW
30
ARDTSGAESL
40
GLWPLPFAVD
50
ISPRSLHLSP
60
NNFFFGHSPT
70
SKAGSSCEIL
80
QEAFRRYYDF
90
IFGFYKWHQG
100
SYQLCFGTEL
110
QQLQVHVESE
120
CDTFPSISSN
130
ESYVLHVKGP
140
EALLRANTVW
150
GALRGLETFS
160
QLIYQDSYGT
170
FTVNESEIID
180
FPRFPHRGIL
190
IDTGRHFLSV
200
KTIFKTLDAM
210
AFNKFNVLHW
220
HIVDDQSFPY
230
QSINFGVLSS
240
KGSYSLSHVY
250
TPNDVRMVIE
260
YARIRGIRVM
270
PEFDTPGHSR
280
SWGKGQKDLL
290
TPCYRKQVLS
300
GTFGPINPIL
310
NTTYNFLSKF
320
FKEISTVFPD
330
EFIHIGGDEV
340
DFDCWASNSE
350
ILQFMQEKGF
360
SQISLNSNLC
370
TVFKISNMIS
380
AMKKRPIVWQ
390
EAFDGRDKFM
400
PGTVVQVWKI
410
EDYKWEQSLI
420
TKAGFPVILS
430
APWYLDLISY
440
GQDWKNYYEV
450
EPQDFPGSDK
460
ERKRVLGGEA
470
CLWGEYVDAT
480
NLTPRLWPRA
490
SAVGERLWSH
500
KDVRDIHDAY
510
SRLTIHRCRM
520
VRRGIAAEPL
530
FTGYCNHEHR
M
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0060473 |
cortical granule |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0004563 |
beta-N-acetylhexosaminidase activity |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:0006689 |
ganglioside catabolic process |
| Biological Process |
GO:0030203 |
glycosaminoglycan metabolic process |
| Biological Process |
GO:0006491 |
N-glycan processing |
| Biological Process |
GO:0007338 |
single fertilization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.