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Overview

Uniprot IDQ29RF7
Protein NameSister chromatid cohesion protein PDS5 homolog A
Gene NamePDS5A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1146 GVLGAVNKPLSATGR
1211 IISVTPVKNIDPVKN
1217 VKNIDPVKNKEINSD
1219 NIDPVKNKEINSDQA
1267 SGPPAPSKPRRGRRP
1284 ESQGNATKNDDLNKP
1290 TKNDDLNKPINKGRK
1294 DLNKPINKGRKRAAV
1315 GLEAGNAKAPKLQDL
1318 AGNAKAPKLQDLAKK
1324 PKLQDLAKKAAPAER
1325 KLQDLAKKAAPAERQ
601 ARKLANPKQPTNPFL

Function

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair

Protein Sequence

10 MDFTAQPKPA 20 TALCGVVSAD 30 GKIAYPPGVK 40 EITDKITTDE 50 MIKRLKMVVK 60 TFMDMDQDSE 70 DEKQQYLPLA 80 LHLASEFFLR 90 NPNKDVRLLV 100 ACCLADIFRI 110 YAPEAPYTSH 120 DKLKDIFLFI 130 TRQLKGLEDT 140 KSPQFNRYFY 150 LLENLAWVKS 160 YNICFELEDC 170 NEIFIQLFRT 180 LFSVINNSHN 190 KKVQMHMLDL 200 MSSIIMEGDG 210 VTQELLDSIL 220 INLIPAHKNL 230 NKQSFDLAKV 240 LLKRTVQTIE 250 ACIANFFNQV 260 LVLGRSSVSD 270 LSEHVFDLIQ 280 ELFAIDPHLL 290 LSVMPQLEFK 300 LKSNDGEERL 310 AVVRLLAKLF 320 GSKDSDLATQ 330 NRPLWQCFLG 340 RFNDIHVPVR 350 LESVKFASHC 360 LMNHPDLAKD 370 LTEYLKVRSH 380 DPEEAIRHDV 390 IVTIITAAKR 400 DLALVNDQLL 410 GFVRERTLDK 420 RWRVRKEAMM 430 GLAQLYKKYC 440 LHGEAGKEAA 450 EKVSWIKDKL 460 LHIYYQNSID 470 DKLLVEKIFA 480 QYLVPHNLET 490 EERMKCLYYL 500 YASLDPNAVK 510 ALNEMWKCQN 520 MLRSHVRELL 530 DLHKQPTSEA 540 NCSAMFGKLM 550 TIAKNLPDPG 560 KAQDFVKKFN 570 QVLGDDEKLR 580 SQLELLISPT 590 CSCKQADICV 600 REIARKLANP 610 KQPTNPFLEM 620 VKFLLERIAP 630 VHIDSEAISA 640 LVKLMNKSIE 650 GTADDEEEGV 660 SPDTAIRSGL 670 ELLKVLSFTH 680 PTSFHSAETY 690 ESLLQCLRME 700 DDKVAEAAIQ 710 IFRNTGHKIE 720 TDLPQIRSTL 730 IPILHQKAKR 740 GTPHQAKQAV 750 HCIHAIFTNK 760 EVQLAQIFEP 770 LSRSLNADVP 780 EQLITPLVSL 790 GHISMLAPDQ 800 FASPMKSVVA 810 NFIVKDLLMN 820 DRSTGEKNGK 830 LWSPDEEVSP 840 EVLAKVQAIK 850 LLVRWLLGMK 860 NNQSKSANST 870 LRLLSAMLVS 880 EGDLTEQKRI 890 SKSDMSRLRL 900 AAGSAIMKLA 910 QEPCYHEIIT 920 PEQFQLCALV 930 INDECYQVRQ 940 IFAQKLHKAL 950 VKLLLPLEYM 960 AIFALCAKDP 970 VKERRAHARQ 980 CLLKNISIRR 990 EYIKQNPMAT 1000 EKLLSLLPEY 1010 VVPYMIHLLA 1020 HDPDFTRSQD 1030 VDQLRDIKEC 1040 LWFMLEVLMT 1050 KNENNSHAFM 1060 KKMAENIKLT 1070 RDAQSPDESK 1080 TNEKLYTVCD 1090 VALCVINSKS 1100 ALCNADSPKD 1110 PVLPMKFFTQ 1120 PEKDFCNDKS 1130 YISEETRVLL 1140 LTGKPKPAGV 1150 LGAVNKPLSA 1160 TGRKPYVRST 1170 GTETGSNINV 1180 NSELNPSTGN 1190 RSREQSSEAA 1200 ETGVSENEEN 1210 PVRIISVTPV 1220 KNIDPVKNKE 1230 INSDQATQGN 1240 ISSDRGKKRT 1250 VTAAGAENIQ 1260 QKTDEKVDES 1270 GPPAPSKPRR 1280 GRRPKSESQG 1290 NATKNDDLNK 1300 PINKGRKRAA 1310 VGQESPGGLE 1320 AGNAKAPKLQ 1330 DLAKKAAPAE RQIDLQR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005694 chromosome
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140670 cohesin unloader activity
Biological Process GO:0051301 cell division
Biological Process GO:0007064 mitotic sister chromatid cohesion
Biological Process GO:0008156 negative regulation of DNA replication

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.