Overview
| Uniprot ID | Q2EN81 |
|---|
| Protein Name | ATP synthase peripheral stalk subunit OSCP, mitochondrial |
|---|
| Gene Name | ATP5PO |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 162 |
TELKTVLKSFLSKGQ |
| 167 |
VLKSFLSKGQILKLE |
| 172 |
LSKGQILKLEVKVDP |
| 51 |
ALYSAASKQNKLEQV |
| 54 |
SAASKQNKLEQVEKE |
| 60 |
NKLEQVEKELLRVAQ |
| 70 |
LRVAQILKEPKVAAS |
| 98 |
SLSDMTAKEKFSPLT |
Function
Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)
Protein Sequence
10
MASQAVSGLS
20
RQVRCFSTSV
30
VRPFAKLVRP
40
PVQIYGIEGR
50
YATALYSAAS
60
KQNKLEQVEK
70
ELLRVAQILK
80
EPKVAASIMN
90
PYVKRSVKVK
100
SLSDMTAKEK
110
FSPLTSNLIN
120
LLAENGRLSS
130
TPGVISAFST
140
MMSVHRGEVP
150
CSVTTASPLD
160
EATLTELKTV
170
LKSFLSKGQI
180
LKLEVKVDPS
190
IMGGMIVRIG
200
EKYVDMSAKT
210
KIQKLSRAMR
EIF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0046933 |
proton-transporting ATP synthase activity, rotational mechanism |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.