Search Results
Overview
| Uniprot ID | Q2F7Z7 |
|---|---|
| Protein Name | Transmembrane protein 59 |
| Gene Name | TMEM59 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 63 | YPLHTYPKEEELYAC |
Function
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding
Protein Sequence
10
MAAPKGSLWV
20
RAQLGLLPLL
30
LLTMALAGGP
40
GTASAEAFDS
50
VLGDTASCHR
60
ACQLTYPLHT
70
YPKEEELYAC
80
QRGCRLFSIC
90
QFVDDGIDLN
100
RTKLECESAC
110
TEAYSQSDEQ
120
YACHLGCQNQ
130
LPFAELRQEQ
140
LMSLMPKMHL
150
LFPLTLVRSF
160
WSDVMDSAQS
170
FITSSWTFYL
180
QADDGKIVIF
190
QSKPEIQYAP
200
QLEQEPTNLK
210
ESSLSKMSYL
220
QMRSSQAHRN
230
YLEDGENDGF
240
LRCLSLNSGW
250
ILTMTLVLSV
260
MVLLWICCAT
270
VATAVEQYVP
280
SEKLSIYGDL
290
EFVNEQKLNR
300
YPASSLVLVR
310
SKAEDHDEAG
320
PLPTKVNLAH
SEI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0010508 | positive regulation of autophagy |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.