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Overview

Uniprot IDQ2I6B4
Protein NameV-type proton ATPase subunit a
Gene NameAtp6v0a1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
119 NTNQEALKRNFLELT
242 QLKNRVKKICEGFRA
262 PETPQERKEMASGVN
295 RVLQAAAKNIRVWFI
50 DVNVFQRKFVNEVRR
674 RHQYLRKKHLGTLNF

Function

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase

Protein Sequence

10 MGELFRSEEM 20 TLAQLFLQSE 30 AAYCCVSELG 40 ELGKVQFRDL 50 NPDVNVFQRK 60 FVNEVRRCEE 70 MDRKLRFVEK 80 EIRKANIPIM 90 DTGENPEVPF 100 PRDMIDLEAN 110 FEKIENELKE 120 INTNQEALKR 130 NFLELTELKF 140 ILRKTQQFFD 150 EAELHHQQMA 160 DPDLLEESSS 170 LLEPNEMGRG 180 APLRLGFVAG 190 VINRERIPTF 200 ERMLWRVCRG 210 NVFLRQAEIE 220 NPLEDPVTGD 230 YVHKSVFIIF 240 FQGDQLKNRV 250 KKICEGFRAS 260 LYPCPETPQE 270 RKEMASGVNT 280 RIDDLQMVLN 290 QTEDHRQRVL 300 QAAAKNIRVW 310 FIKVRKMKAI 320 YHTLNLCNID 330 VTQKCLIAEV 340 WCPVTDLDSI 350 QFALRRGTEH 360 SGSTVPSILN 370 RMQTNQTPPT 380 YNKTNKFTHG 390 FQNIVDAYGI 400 GTYREINPAP 410 YTVITFPFLF 420 AVMFGDFGHG 430 ILMTLFAVWM 440 VLRESRILSQ 450 KNENEMFSMV 460 FSGRYIILLM 470 GLFSIYTGLI 480 YNDCFSKSLN 490 IFGSSWSVRP 500 MFTIGNWTEE 510 TLLGSSVLQL 520 NPAIPGVFGG 530 PYPFGIDPIW 540 NIATNKLTFL 550 NSFKMKMSVI 560 LGIIHMLFGV 570 SLSLFNHIYF 580 KKPLNIYFGF 590 IPEIIFMSSL 600 FGYLVILIFY 610 KWTAYDAHSS 620 RNAPSLLIHF 630 INMFLFSYPE 640 SGNAMLYSGQ 650 KGIQCFLIVV 660 AMLCVPWMLL 670 FKPLILRHQY 680 LRKKHLGTLN 690 FGGIRVGNGP 700 TEEDAEIIQH 710 DQLSTHSEDA 720 EEPTEDEVFD 730 FGDTMVHQAI 740 HTIEYCLGCI 750 SNTASYLRLW 760 ALSLAHAQLS 770 EVLWTMVIHI 780 GLHVRSLAGG 790 LGLFFIFAAF 800 ATLTVAILLI 810 MEGLSAFLHA 820 LRLHWVEFQN 830 KFYTGTGFKF 840 LPFSFEHIRE GKFDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0042470 melanosome
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.