Overview
| Uniprot ID | Q2IBC6 |
|---|
| Protein Name | Caveolin |
|---|
| Gene Name | Cav1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 30 |
NIYKPNNKAMADEVN |
| 39 |
MADEVNEKQVYDAHT |
| 57 |
DLVNRDPKHLNDDVV |
Function
May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Binds 20(S)-hydroxycholesterol (20(S)-OHC)
Protein Sequence
10
MSGGKYVDSE
20
GHLYTVPIRE
30
QGNIYKPNNK
40
AMADEVNEKQ
50
VYDAHTKEID
60
LVNRDPKHLN
70
DDVVKIDFED
80
VIAEPEGTHS
90
FDGIWKASFT
100
TFTVTKYWFY
110
RLLSTIFGIP
120
MALIWGIYFA
130
ILSFLHIWAV
140
VPCIKSFLIE
150
IQCISRVYSI
160
YVHTFCDPLF
170
EAIGKIFSNI
RISTQKEI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005901 |
caveola |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Biological Process |
GO:0070836 |
caveola assembly |
| Biological Process |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.