Search Results

Overview

Uniprot IDQ2IBD4
Protein NameCortactin-binding protein 2
Gene NameCttnbp2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
572 AGAKVDNKIVASPPS

Function

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance (PubMed:22262902). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons (PubMed:23015759)

Protein Sequence

10 MATDSASCEP 20 DLSRAPGDAE 30 GATAEAAKKE 40 FDVDTLSKSE 50 LRMLLSVMEG 60 ELEARDLVIE 70 ALRARRKEVF 80 IQERYGRFNL 90 NDPFLALQRD 100 YEAGAGDKEK 110 PVCTNPLSIL 120 EAVMAHCRKM 130 QERMSAQLAA 140 AESRQKKLEM 150 EKLQLQALEQ 160 EHKKLAAHLE 170 EERGKNKHVV 180 LMLVKECKQL 190 SGKVVEEAQK 200 LEEVMVKLEE 210 EKKKTSELED 220 QLSAEKQRSA 230 GMEAQLEKQL 240 FEFDTEREQL 250 RAKLTREEAH 260 TTDLKEEIDK 270 MKKMMEQMKK 280 GNDGKPGLSL 290 PRKTKDKRLA 300 SISVATEGPV 310 TRSVACQTDV 320 VTESTDPVKK 330 LPLSVPIKPS 340 TGSPLVSTNT 350 KGNVGPSALL 360 IRPGIDRQAS 370 HSDLGPSPPT 380 ALPSSASRIE 390 ENGPSAGNAP 400 DLSNSTPSTP 410 SGTAPAAAQT 420 LGAAPQNHSQ 430 APPVHSLHSP 440 CANTHPGLNP 450 RIQAARFRFQ 460 GNANDPDQNG 470 NNTQSPPSRD 480 VSPTSRDNLV 490 AKQLARNTVT 500 QALSRFTSPQ 510 AGASSRLGAS 520 PGGDAGTCPP 530 VGRTGLKTPG 540 AARVDRGNPP 550 PIPPKKPGLS 560 QTPSPPHPQL 570 RASNAGAKVD 580 NKIVASPPST 590 LPQGTKVVNE 600 ENVPKSSSPQ 610 LPPKPSIDLT 620 VASAGCPVSA 630 LATSQVGAWP 640 AETPGLNQPA 650 CTDSSLVIPT 660 TVAFRSSINP 670 VSASSRSPGA 680 SDSLLVTASG 690 WSPSLTPLLM 700 SGGPAPLAGR 710 PTLLQQAAAQ 720 GNVTLLSMLL 730 NEEGLDINYC 740 CEDSHSALYS 750 AAKNGHTDCV 760 RLLLNAEARV 770 DAADKNGFTP 780 LCVAAAQGHF 790 ECIELLTAYN 800 ANINHSAAGG 810 QTPLYLACKT 820 GNKECIKLLL 830 EAGTDRSIKT 840 RDGWTPIHAA 850 VDTGNVDSLK 860 LLMYHRVPAP 870 GNSLSAEEPK 880 SGLFSLNGGE 890 SPPGSSKPVV 900 PADLINHADK 910 EGWTAAHIAA 920 SKGFKNCLEI 930 LCRHGGLEPE 940 RRDKCNRTVH 950 DVATDDCKHL 960 LENLNALKIP 970 LRISVGEIQP 980 SNDGSDDFEC 990 EHTICTLNIR 1000 KQTSWEDFSK 1010 AVSQALTNHF 1020 QAISSDGCWG 1030 LEDGTLNNTT 1040 DSCIGLGTSS 1050 IQSIMLGSIP 1060 WSTGQSFSQS 1070 PWDFMKKKKV 1080 EQVTVLLSGP 1090 QEGCLSSVTY 1100 TSMIPLQMLQ 1110 NYLRLVEQYH 1120 NVIFHGPEGS 1130 LQDYIANQLA 1140 LCMKHRQMAA 1150 GFPCEIVRAE 1160 VDSGFSKEQL 1170 VDVFISNACL 1180 IPVKQFPVKK 1190 KIIVILENLE 1200 KSSLSELLGD 1210 FLAPLENRST 1220 ESPCTFQKGN 1230 GTSECYYFHE 1240 NCFLLGTLAK 1250 ACLQGSDLLV 1260 QQHFRWVQLR 1270 WDCEPSQGLL 1280 QRFLRRKAVS 1290 KFRGQLPAPC 1300 DPVCKIVDWV 1310 ISVWRQLNSC 1320 LARLGTPEAL 1330 LGPKYFLSCP 1340 VVPGHAQATV 1350 KWMSKLWNAI 1360 IAPRVQEAIL 1370 SRAAMNKQPG 1380 ARQTASKKHP 1390 SQGQQAVVRA 1400 ALSILLNKAI 1410 LHGCPLPRTE 1420 LDQQIADFKG 1430 GSFPLSIVSS 1440 YSKKKGESAA 1450 WRKVNTSPRK 1460 KPGHFSSPMW 1470 NKPDLKHEGM 1480 RNKSVPHLNI 1490 NRSSSLSKQQ 1500 SLENDLSMTL 1510 TLDHRLSLGS 1520 DDEADLVKEL 1530 QSMCSSKSES 1540 DISKIADSRE 1550 DLRTFDSSRT 1560 NPVTSAPVNL 1570 RMPVPQKEAS 1580 PLSSHQTTEC 1590 SNSKSKTELG 1600 VSRVKSFLPV 1610 PRSKVAQCSQ 1620 NTKRSSSSSS 1630 NTRQLEINNN 1640 SKEENWNVDK HEHVEKRNK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0090443 FAR/SIN/STRIPAK complex
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098871 postsynaptic actin cytoskeleton
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0017124 SH3 domain binding
Biological Process GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
Biological Process GO:0050807 regulation of synapse organization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.