Search Results

Overview

Uniprot IDQ2KHR3
Protein NameGlutamine and serine-rich protein 1
Gene NameQSER1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1091 EEDNSNQKQLKRPAQ
1130 DGYQHQEKMRQKIKE
1259 TLDATSDKKKKTEAL
1260 LDATSDKKKKTEALQ
1388 PAIWKVQKALLQKFV
1466 AKPSSSSKTSDPLAS
1474 TSDPLASKTTTTKAP
1479 ASKTTTTKAPSVKPK
1486 KAPSVKPKVKQPKVK
1493 KVKQPKVKAEPPPKK
1625 ITRDSKAKSGGTAIS
1654 RTSKTTTKSAQEFAV
368 YRSSKVEKLPPLYKT
674 PQIRLNTKDLKQQHP
812 LQQHLTTKGHFSETN
978 EQSSGPFKKQSATNL
979 QSSGPFKKQSATNLE

Function

Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation

Protein Sequence

10 MNFLSTAESR 20 TAQAAASGTT 30 LLPQFRAPSW 40 QTGMHSSAAT 50 ELFATGPLPS 60 TGTLPPSLSA 70 YQHPTTFSNR 80 NFATTSPLVL 90 QDSTFNTTSN 100 GILSHHDPLL 110 QIKTSQGTVP 120 TALAFERLGS 130 SVLSNSIPPQ 140 SSTYRSAQES 150 APHLLQPQFS 160 LLPSALGGSQ 170 QTPQAYSSTL 180 FTSSTASIER 190 ALLRECSVIK 200 HHQRPSGTQS 210 IQAQLTGSQH 220 SLHSYLSNSS 230 VVNFQETTRQ 240 SSLSCSPIGD 250 STQVSNGGLQ 260 QKTSQVSVEL 270 AQSYSSAIPS 280 SGYPPSTTKI 290 KSCSTEQPLT 300 STKTPKPQSI 310 IPPVQTLSYS 320 KPLHNQSSVI 330 SGQAQIYSTA 340 QLPSLLSVSQ 350 SQNYGLVQPH 360 NVPSIVHSQV 370 YRSSKVEKLP 380 PLYKTLTFSG 390 SSQTVTPENQ 400 TLNYSSNQQE 410 VLSSVTNENY 420 PAQTRDLSSV 430 SQSQSYSSGH 440 SQGLSPVSQT 450 QVSYSSQSQV 460 LSVVSLSESY 470 ASGESLTLTA 480 PSLSYSSASR 490 AQNLPDSSPT 500 QNYISMHSSQ 510 NVQTQESSSP 520 QSQKFLPAVQ 530 SSSFASSTHC 540 QTLQNNITSP 550 DPKSYAERKL 560 DSDVYPSSKQ 570 EDGFPMQELQ 580 VLQPQASLES 590 STQRLSDGEI 600 NAQESTYKVS 610 KADDRYSQSV 620 IRSNSRLEDQ 630 VIGVALQASK 640 KEESVVGSVT 650 QLNQQIGQVN 660 NAATLDLKNS 670 TNLIQTPQIR 680 LNTKDLKQQH 690 PLILKVHESK 700 VQEQHDQIIN 710 ASSQIQIPNH 720 ALGHGHQASL 730 PNTQVLLDSA 740 CDLQILQQSI 750 LQAGLGQVKA 760 SLQAQRVQSP 770 QQIVHPFLQM 780 EGHVIQSNGD 790 HSQQQLHPQN 800 SEVMKMDLSE 810 SSKPLQQHLT 820 TKGHFSETNQ 830 HDSKNQFVSL 840 GSMCFPEAVL 850 LSDERNILSN 860 VDDILAATAA 870 ACGVTPTDFS 880 KSTSNETMQA 890 VEDGDSKSHF 900 QQSLDVRHVT 910 SDFNSMTATV 920 GKPQNINDTS 930 LNGNQVTVNL 940 SPVPALQSKM 950 TLDQQHIETP 960 GQNIPTKVTS 970 AVVGPSHEVQ 980 EQSSGPFKKQ 990 SATNLESEED 1000 SEAPVDSTLN 1010 NNRNQEFVSS 1020 SRSISGENAT 1030 SESEFTLGGD 1040 DSGVSMNPAR 1050 SALALLAMAQ 1060 SGDAVSVKIE 1070 EENQDLMHFN 1080 LQKKRAKGKG 1090 QVKEEDNSNQ 1100 KQLKRPAQGK 1110 RQNPRGTDIY 1120 LPYTPPSSES 1130 CHDGYQHQEK 1140 MRQKIKEVEE 1150 KQPEVKTGFI 1160 ASFLDFLKSG 1170 PKQQFSTLAV 1180 RMPNRTRRPG 1190 TQMVRTFCPP 1200 PLPKPSSTTP 1210 TPLVSETGGN 1220 SPSDKVDNEL 1230 KNLEHLSSFS 1240 SDEDDPGYSQ 1250 DAYKSVSTPL 1260 TTLDATSDKK 1270 KKTEALQVAT 1280 TSPTANTTGT 1290 ATTSSTTVGA 1300 VKQEPLHSTS 1310 YAVNILENIS 1320 SSESSKPIEL 1330 DGLPSDQFAK 1340 GQDTVAIEGF 1350 TDEEDTESGG 1360 EGQYRERDEF 1370 VVKIEDIETF 1380 KEALKTGKEP 1390 PAIWKVQKAL 1400 LQKFVPEIRD 1410 GQREFAATNS 1420 YLGYFGDAKS 1430 KYKRIYVKFI 1440 ENANKKEYVR 1450 VCSKKPRNKP 1460 SQTIRTVQAK 1470 PSSSSKTSDP 1480 LASKTTTTKA 1490 PSVKPKVKQP 1500 KVKAEPPPKK 1510 RKKWKEEFSS 1520 SQSDSSPEIH 1530 TSSSDDEEFE 1540 PPAPFVTRFL 1550 NTRAMKETFK 1560 SYMELLVSIA 1570 LDPDTMQALE 1580 KSNDELLLPH 1590 MKKIDGMLND 1600 NRKRLLLNLH 1610 LDQSFKNALE 1620 SFPELTIITR 1630 DSKAKSGGTA 1640 ISKIKMNGKA 1650 YNKKTLRTSK 1660 TTTKSAQEFA 1670 VDPEKIQLYS 1680 LYHSLHHYKY 1690 HVYLICKDEI 1700 SSVQKKNEDL 1710 GQEEIVQLCM 1720 KNVKWVEDLF 1730 EKFGELLNHV QQKCS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.