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Overview

Uniprot IDQ2M1K9
Protein NameZinc finger protein 423
Gene NameZNF423
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
927 RKKAEFIKGSHKCNV
931 EFIKGSHKCNVCSRT

Function

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation

Protein Sequence

10 MHKKRVEEGE 20 ASDFSLAWDS 30 SVTAAGGLEG 40 EPECDQKTSR 50 ALEDRNSVTS 60 QEERNEDDED 70 MEDESIYTCD 80 HCQQDFESLA 90 DLTDHRAHRC 100 PGDGDDDPQL 110 SWVASSPSSK 120 DVASPTQMIG 130 DGCDLGLGEE 140 EGGTGLPYPC 150 QFCDKSFIRL 160 SYLKRHEQIH 170 SDKLPFKCTY 180 CSRLFKHKRS 190 RDRHIKLHTG 200 DKKYHCHECE 210 AAFSRSDHLK 220 IHLKTHSSSK 230 PFKCTVCKRG 240 FSSTSSLQSH 250 MQAHKKNKEH 260 LAKSEKEAKK 270 DDFMCDYCED 280 TFSQTEELEK 290 HVLTRHPQLS 300 EKADLQCIHC 310 PEVFVDENTL 320 LAHIHQAHAN 330 QKHKCPMCPE 340 QFSSVEGVYC 350 HLDSHRQPDS 360 SNHSVSPDPV 370 LGSVASMSSA 380 TPDSSASVER 390 GSTPDSTLKP 400 LRGQKKMRDD 410 GQGWTKVVYS 420 CPYCSKRDFN 430 SLAVLEIHLK 440 TIHADKPQQS 450 HTCQICLDSM 460 PTLYNLNEHV 470 RKLHKNHAYP 480 VMQFGNISAF 490 HCNYCPEMFA 500 DINSLQEHIR 510 VSHCGPNANP 520 SDGNNAFFCN 530 QCSMGFLTES 540 SLTEHIQQAH 550 CSVGSAKLES 560 PVVQPTQSFM 570 EVYSCPYCTN 580 SPIFGSILKL 590 TKHIKENHKN 600 IPLAHSKKSK 610 AEQSPVSSDV 620 EVSSPKRQRL 630 SASANSISNG 640 EYPCNQCDLK 650 FSNFESFQTH 660 LKLHLELLLR 670 KQACPQCKED 680 FDSQESLLQH 690 LTVHYMTTST 700 HYVCESCDKQ 710 FSSVDDLQKH 720 LLDMHTFVLY 730 HCTLCQEVFD 740 SKVSIQVHLA 750 VKHSNEKKMY 760 RCTACNWDFR 770 KEADLQVHVK 780 HSHLGNPAKA 790 HKCIFCGETF 800 STEVELQCHI 810 TTHSKKYNCK 820 FCSKAFHAII 830 LLEKHLREKH 840 CVFDAATENG 850 TANGVPPMAT 860 KKAEPADLQG 870 MLLKNPEAPN 880 SHEASEDDVD 890 ASEPMYGCDI 900 CGAAYTMEVL 910 LQNHRLRDHN 920 IRPGEDDGSR 930 KKAEFIKGSH 940 KCNVCSRTFF 950 SENGLREHLQ 960 THRGPAKHYM 970 CPICGERFPS 980 LLTLTEHKVT 990 HSKSLDTGTC 1000 RICKMPLQSE 1010 EEFIEHCQMH 1020 PDLRNSLTGF 1030 RCVVCMQTVT 1040 STLELKIHGT 1050 FHMQKLAGSS 1060 AASSPNGQGL 1070 QKLYKCALCL 1080 KEFRSKQDLV 1090 KLDVNGLPYG 1100 LCAGCMARSA 1110 NGQVGGLAPP 1120 EPADRPCAGL 1130 RCPECSVKFE 1140 SAEDLESHMQ 1150 VDHRDLTPET 1160 SGPRKGTQTS 1170 PVPRKKTYQC 1180 IKCQMTFENE 1190 REIQIHVANH 1200 MIEEGINHEC 1210 KLCNQMFDSP 1220 AKLLCHLIEH 1230 SFEGMGGTFK 1240 CPVCFTVFVQ 1250 ANKLQQHIFA 1260 VHGQEDKIYD 1270 CSQCPQKFFF 1280 QTELQNHTMS QHAQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0007399 nervous system development
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0030513 positive regulation of BMP signaling pathway
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0061512 protein localization to cilium
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.