Search Results

Overview

Uniprot ID	Q2M1P5
Protein Name	Kinesin-like protein KIF7
Gene Name	KIF7
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
129	RAMAEAFKLIDENDL

Function

Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity)

Protein Sequence

10 MGLEAQRLPG 20 AEEAPVRVAL 30 RVRPLLPKEL 40 LHGHQSCLQV 50 EPGLGRVTLG 60 RDRHFGFHVV 70 LAEDAGQEAV 80 YQACVQPLLE 90 AFFEGFNATV 100 FAYGQTGSGK 110 TYTMGEASVA 120 SLLEDEQGIV 130 PRAMAEAFKL 140 IDENDLLDCL 150 VHVSYLEVYK 160 EEFRDLLEVG 170 TASRDIQLRE 180 DERGNVVLCG 190 VKEVDVEGLD 200 EVLSLLEMGN 210 AARHTGATHL 220 NHLSSRSHTV 230 FTVTLEQRGR 240 APSRLPRPAP 250 GQLLVSKFHF 260 VDLAGSERVL 270 KTGSTGERLK 280 ESIQINSSLL 290 ALGNVISALG 300 DPQRRGSHIP 310 YRDSKITRIL 320 KDSLGGNAKT 330 VMIACVSPSS 340 SDFDETLNTL 350 NYASRAQNIR 360 NRATVNWRPE 370 AERPPEETAS 380 GARGPPRHRS 390 ETRIIHRGRR 400 APGPATASAA 410 AAMRLGAECA 420 RYRACTDAAY 430 SLLRELQAEP 440 GLPGAAARKV 450 RDWLCAVEGE 460 RSALSSASGP 470 DSGIESASVE 480 DQAAQGAGGR 490 KEDEGAQQLL 500 TLQNQVARLE 510 EENRDFLAAL 520 EDAMEQYKLQ 530 SDRLREQQEE 540 MVELRLRLEL 550 VRPGWGGPRL 560 LNGLPPGSFV 570 PRPHTAPLGG 580 AHAHVLGMVP 590 PACLPGDEVG 600 SEQRGEQVTN 610 GREAGAELLT 620 EVNRLGSGSS 630 AASEEEEEEE 640 EPPRRTLHLR 650 RNRISNCSQR 660 AGARPGSLPE 670 RKGPELCLEE 680 LDAAIPGSRA 690 VGGSKARVQA 700 RQVPPATASE 710 WRLAQAQQKI 720 RELAINIRMK 730 EELIGELVRT 740 GKAAQALNRQ 750 HSQRIRELEQ 760 EAEQVRAELS 770 EGQRQLRELE 780 GKELQDAGER 790 SRLQEFRRRV 800 AAAQSQVQVL 810 KEKKQATERL 820 VSLSAQSEKR 830 LQELERNVQL 840 MRQQQGQLQR 850 RLREETEQKR 860 RLEAEMSKRQ 870 HRVKELELKH 880 EQQQKILKIK 890 TEEIAAFQRK 900 RRSGSNGSVV 910 SLEQQQKIEE 920 QKKWLDQEME 930 KVLQQRRALE 940 ELGEELHKRE 950 AILAKKEALM 960 QEKTGLESKR 970 LRSSQALNED 980 IVRVSSRLEH 990 LEKELSEKSG 1000 QLRQGSAQSQ 1010 QQIRGEIDSL 1020 RQEKDSLLKQ 1030 RLEIDGKLRQ 1040 GSLLSPEEER 1050 TLFQLDEAIE 1060 ALDAAIEYKN 1070 EAITCRQRVL 1080 RASASLLSQC 1090 EMNLMAKLSY 1100 LSSSETRALL 1110 CKYFDKVVTL 1120 REEQHQQQIA 1130 FSELEMQLEE 1140 QQRLVYWLEV 1150 ALERQRLEMD 1160 RQLTLQQKEH 1170 EQNMQLLLQQ 1180 SRDHLGEGLA 1190 DSRRQYEARI 1200 QALEKELGRY 1210 MWINQELKQK 1220 LGGVNAVGHS 1230 RGGEKRSLCS 1240 EGRQAPGNED 1250 ELHLAPELLW 1260 LSPLTEGAPR 1270 TREETRDLVH 1280 APLPLTWKRS 1290 SLCGEEQGSP 1300 EELRQREAAE 1310 PLVGRVLPVG 1320 EAGLPWNFGP 1330 LSKPRRELRR 1340 ASPGMIDVRK NPL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0036064	ciliary basal body
Cellular Component	GO:0097542	ciliary tip
Cellular Component	GO:0005929	cilium
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005871	kinesin complex
Cellular Component	GO:0005874	microtubule
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0003777	microtubule motor activity
Biological Process	GO:0007018	microtubule-based movement
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.