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Overview

Uniprot IDQ2M389
Protein NameWASH complex subunit 4
Gene NameWASHC4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1089 KEIRAVAKQQNVQSA
378 AAKLLDRKSLQAIKI

Function

Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting

Protein Sequence

10 MAVETLSPDW 20 EFDRVDDGSQ 30 KIHAEVQLKN 40 YGKFLEEYTS 50 QLRRIEDALD 60 DSIGDVWDFN 70 LDPIALKLLP 80 YEQSSLLELI 90 KTENKVLNKV 100 ITVYAALCCE 110 IKKLKYEAET 120 KFYNGLLFYG 130 EGATDASMVE 140 GDCQIQMGRF 150 ISFLQELSCF 160 VTRCYEVVMN 170 VVHQLAALYI 180 SNKIAPKIIE 190 TTGVHFQTMY 200 EHLGELLTVL 210 LTLDEIIDNH 220 ITLKDHWTMY 230 KRLLKSVHHN 240 PSKFGIQEEK 250 LKPFEKFLLK 260 LEGQLLDGMI 270 FQACIEQQFD 280 SLNGGVSVSK 290 NSTFAEEFAH 300 SIRSIFANVE 310 AKLGEPSEID 320 QRDKYVGICG 330 LFVLHFQIFR 340 TIDKKFYKSL 350 LDICKKVPAI 360 TLTANIIWFP 370 DNFLIQKIPA 380 AAKLLDRKSL 390 QAIKIHRDTF 400 LQQKAQSLTK 410 DVQSYYVFVS 420 SWMMKMESIL 430 SKEQRMDKFA 440 EDLTNRCNVF 450 IQGFLYAYSI 460 STIIKTTMNL 470 YMSMQKPMTK 480 TSVKALCRLV 490 ELLKAIEHMF 500 YRRSMVVADS 510 VSHITQHLQH 520 QALHSISVAK 530 KRVISDKKYS 540 EQRLDVLSAL 550 VLAENTLNGP 560 STKQRRLIVS 570 LALSVGTQMK 580 TFKDEELFPL 590 QVVMKKLDLI 600 SELRERVQTQ 610 CDCCFLYWHR 620 AVFPIYLDDV 630 YENAVDAARL 640 HYMFSALRDC 650 VPAMMHARHL 660 ESYEILLDCY 670 DKEIMEILNE 680 HLLDKLCKEI 690 EKDLRLSVHT 700 HLKLDDRNPF 710 KVGMKDLALF 720 FSLNPIRFFN 730 RFIDIRAYVT 740 HYLDKTFYNL 750 TTVALHDWAT 760 YSEMRNLATQ 770 RYGLVMTEAH 780 LPSQTLEQGL 790 DVLEIMRNIH 800 IFVSRYLYNL 810 NNQIFIERTS 820 NNKHLNTINI 830 RHIANSIRTH 840 GTGIMNTTVN 850 FTYQFLKKKF 860 YIFSQFMYDE 870 HIKSRLIKDI 880 RFFREIKDQN 890 DHKYPFDRAE 900 KFNRGIRKLG 910 VTPEGQSYLD 920 QFRQLISQIG 930 NAMGYVRMIR 940 SGGLHCSSNA 950 IRFVPDLEDI 960 VNFEELVKEE 970 GLAEETLKAA 980 RHLDSVLSDH 990 TRNSAEGTEY 1000 FKMLVDVFAP 1010 EFRRPKNIHL 1020 RNFYIIVPPL 1030 TLNFVEHSIS 1040 CKEKLNKKNK 1050 IGAAFTDDGF 1060 AMGVAYILKL 1070 LDQYREFDSL 1080 HWFQSVREKY 1090 LKEIRAVAKQ 1100 QNVQSASQDE 1110 KLLQTMNLTQ 1120 KRLDVYLQEF 1130 ELLYFSLSSA 1140 RIFFRADKTA 1150 AEENQEKKEK 1160 EEETKTSNGD 1170 LSDSTVSADP VVK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0071203 WASH complex
Biological Process GO:0016197 endosomal transport
Biological Process GO:0007032 endosome organization
Biological Process GO:0140591 nuclear envelope budding
Biological Process GO:0015031 protein transport
Biological Process GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.