Search Results

Overview

Uniprot ID	Q2M3M2
Protein Name	Sodium/glucose cotransporter 4
Gene Name	SLC5A9
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
166	LILYIFTKISTDIFS

Function

Electrogenic Na(+)-coupled sugar symporter that may play a primary role in D-mannose and possibly D-fructose and D-glucose transport at the plasma membrane. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2

Protein Sequence

10 MSKELAAMGP 20 GASGDGVRTE 30 TAPHIALDSR 40 VGLHAYDISV 50 VVIYFVFVIA 60 VGIWSSIRAS 70 RGTIGGYFLA 80 GRSMSWWPIG 90 ASLMSSNVGS 100 GLFIGLAGTG 110 AAGGLAVGGF 120 EWNATWLLLA 130 LGWVFVPVYI 140 AAGVVTMPQY 150 LKKRFGGQRI 160 QVYMSVLSLI 170 LYIFTKISTD 180 IFSGALFIQM 190 ALGWNLYLST 200 GILLVVTAVY 210 TIAGGLMAVI 220 YTDALQTVIM 230 VGGALVLMFL 240 GFQDVGWYPG 250 LEQRYRQAIP 260 NVTVPNTTCH 270 LPRPDAFHIL 280 RDPVSGDIPW 290 PGLIFGLTVL 300 ATWCWCTDQV 310 IVQRSLSAKS 320 LSHAKGGSVL 330 GGYLKILPMF 340 FIVMPGMISR 350 ALFPDEVGCV 360 DPDVCQRICG 370 ARVGCSNIAY 380 PKLVMALMPV 390 GLRGLMIAVI 400 MAALMSSLTS 410 IFNSSSTLFT 420 IDVWQRFRRK 430 STEQELMVVG 440 RVFVVFLVVI 450 SILWIPIIQS 460 SNSGQLFDYI 470 QAVTSYLAPP 480 ITALFLLAIF 490 CKRVTEPGAF 500 WGLVFGLGVG 510 LLRMILEFSY 520 PAPACGEVDR 530 RPAVLKDFHY 540 LYFAILLCGL 550 TAIVIVIVSL 560 CTTPIPEEQL 570 TRLTWWTRNC 580 PLSELEKEAH 590 ESTPEISERP 600 AGECPAGGGA 610 AENSSLGQEQ 620 PEAPSRSWGK 630 LLWSWFCGLS 640 GTPEQALSPA 650 EKAALEQKLT 660 SIEEEPLWRH 670 VCNINAVLLL 680 AINIFLWGYF A

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005362	low-affinity D-glucose:sodium symporter activity
Molecular Function	GO:0022857	transmembrane transporter activity
Biological Process	GO:0008645	hexose transmembrane transport

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.