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Overview

Uniprot IDQ2NKX8
Protein NameDNA excision repair protein ERCC-6-like
Gene NameERCC6L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
703 YIQQRVQKAQFLVEF
874 YVLSKSTKADIGPNL

Function

DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328)

Protein Sequence

10 MEASRRFPEA 20 EALSPEQAAH 30 YLRYVKEAKE 40 ATKNGDLEEA 50 FKLFNLAKDI 60 FPNEKVLSRI 70 QKIQEALEEL 80 AEQGDDEFTD 90 VCNSGLLLYR 100 ELHNQLFEHQ 110 KEGIAFLYSL 120 YRDGRKGGIL 130 ADDMGLGKTV 140 QIIAFLSGMF 150 DASLVNHVLL 160 IMPTNLINTW 170 VKEFIKWTPG 180 MRVKTFHGPS 190 KDERTRNLNR 200 IQQRNGVIIT 210 TYQMLINNWQ 220 QLSSFRGQEF 230 VWDYVILDEA 240 HKIKTSSTKS 250 AICARAIPAS 260 NRLLLTGTPI 270 QNNLQELWSL 280 FDFACQGSLL 290 GTLKTFKMEY 300 ENPITRAREK 310 DATPGEKALG 320 FKISENLMAI 330 IKPYFLRRTK 340 EDVQKKKSSN 350 PEARLNEKNP 360 DVDAICEMPS 370 LSRKNDLIIW 380 IRLVPLQEEI 390 YRKFVSLDHI 400 KELLMETRSP 410 LAELGVLKKL 420 CDHPRLLSAR 430 ACCLLNLGTF 440 SAQDGNEGED 450 SPDVDHIDQV 460 TDDTLMEESG 470 KMIFLMDLLK 480 RLRDEGHQTL 490 VFSQSRQILN 500 IIERLLKNRH 510 FKTLRIDGTV 520 THLLEREKRI 530 NLFQQNKDYS 540 VFLLTTQVGG 550 VGLTLTAATR 560 VVIFDPSWNP 570 ATDAQAVDRV 580 YRIGQKENVV 590 VYRLITCGTV 600 EEKIYRRQVF 610 KDSLIRQTTG 620 EKKNPFRYFS 630 KQELRELFTI 640 EDLQNSVTQL 650 QLQSLHAAQR 660 KSDIKLDEHI 670 AYLQSLGIAG 680 ISDHDLMYTC 690 DLSVKEELDV 700 VEESHYIQQR 710 VQKAQFLVEF 720 ESQNKEFLME 730 QQRTRNEGAW 740 LREPVFPSST 750 KKKCPKLNKP 760 QPQPSPLLST 770 HHTQEEDISS 780 KMASVVIDDL 790 PKEGEKQDLS 800 SIKVNVTTLQ 810 DGKGTGSADS 820 IATLPKGFGS 830 VEELCTNSSL 840 GMEKSFATKN 850 EAVQKETLQE 860 GPKQEALQED 870 PLESFNYVLS 880 KSTKADIGPN 890 LDQLKDDEIL 900 RHCNPWPIIS 910 ITNESQNAES 920 NVSIIEIADD 930 LSASHSALQD 940 AQASEAKLEE 950 EPSASSPQYA 960 CDFNLFLEDS 970 ADNRQNFSSQ 980 SLEHVEKENS 990 LCGSAPNSRA 1000 GFVHSKTCLS 1010 WEFSEKDDEP 1020 EEVVVKAKIR 1030 SKARRIVSDG 1040 EDEDDSFKDT 1050 SSINPFNTSL 1060 FQFSSVKQFD 1070 ASTPKNDISP 1080 PGRFFSSQIP 1090 SSVNKSMNSR 1100 RSLASRRSLI 1110 NMVLDHVEDM 1120 EERLDDSSEA 1130 KGPEDYPEEG 1140 VEESSGEASK 1150 YTEEDPSGET 1160 LSSENKSSWL 1170 MTSKPSALAQ 1180 ETSLGAPEPL 1190 SGEQLVGSPQ 1200 DKAAEATNDY 1210 ETLVKRGKEL 1220 KECGKIQEAL 1230 NCLVKALDIK 1240 SADPEVMLLT 1250 LSLYKQLNNN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016020 membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003678 DNA helicase activity
Molecular Function GO:0015616 DNA translocase activity
Biological Process GO:0051301 cell division
Biological Process GO:0006281 DNA repair

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.