Search Results

Overview

Uniprot IDQ2NL82
Protein NamePre-rRNA-processing protein TSR1 homolog
Gene NameTSR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 AHRPGPLKQQNKAHK
317 PLNPRGIKPQKDPDM
38 GKGRLALKTLSKKVR
65 SQLRKQKKEAVLAEK

Function

Required during maturation of the 40S ribosomal subunit in the nucleolus

Protein Sequence

10 MAAHRPGPLK 20 QQNKAHKGGR 30 HRGRGSAQRD 40 GKGRLALKTL 50 SKKVRKELSR 60 VDQRHRASQL 70 RKQKKEAVLA 80 EKRQLGGKDG 90 PPHQVLVVPL 100 HSRISLPEAM 110 QLLQDRDTGT 120 VHLNELGNTQ 130 NFMLLCPRLK 140 HRWFFTSARP 150 GDLHVVLDMA 160 KVADTILFLL 170 DPLEGWDSTG 180 DYCLSCLFAQ 190 GLPTYTLAVQ 200 GISGLPLKKQ 210 IDTRKKLSKA 220 VEKRFPHDKL 230 LLLDTQQEAG 240 MLLRQLANQK 250 QQHLAFRDRR 260 AYLFAHAVDF 270 VPSEENNLVG 280 TLKISGYVRG 290 QTLNVNRLLH 300 IVGYGDFQMK 310 QIDAPGDPFP 320 LNPRGIKPQK 330 DPDMAMEICA 340 TDAVDDMEEG 350 LKVLMKADPG 360 RQESLQAEVI 370 PDPMEGEQTW 380 PTEEELSEAK 390 DFLKESSKVV 400 KKVPKGTSSY 410 QAEWILDGGS 420 QSGGEGDEYE 430 YDDMEHEDFM 440 EEESQDESSE 450 EEEEYETMTI 460 GESVHDDLYD 470 KKVDEEAEAK 480 MLEKYKQERL 490 EEMFPDEVDT 500 PRDVAARIRF 510 QKYRGLKSFR 520 TSPWDPKENL 530 PQDYARIFQF 540 QNFTNTRKSI 550 FKEVEEKEVE 560 GAEVGWYVTL 570 HVSEVPVSVV 580 ECFRQGTPLI 590 AFSLLPHEQK 600 MSVLNMVVRR 610 DPGNTEPVKA 620 KEELIFHCGF 630 RRFRASPLFS 640 QHTAADKHKL 650 QRFLTADMAL 660 VATVYAPITF 670 PPASVLLFKQ 680 KSNGMHSLIA 690 TGHLMSVDPD 700 RMVIKRVVLS 710 GHPFKIFTKM 720 AVVRYMFFNR 730 EDVLWFKPVE 740 LRTKWGRRGH 750 IKEPLGTHGH 760 MKCSFDGKLK 770 SQDTVLMNLY 780 KRVFPKWTYD 790 PYVPEPVPWL 800 KSEISSTVPQ GGME

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030686 90S preribosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.