Search Results
Overview
| Uniprot ID | Q2PQA9 |
|---|---|
| Protein Name | Kinesin-1 heavy chain |
| Gene Name | Kif5b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 240 | AGSEKVSKTGAEGAV |
| 642 | RISQHEAKIKSLTEY |
| 679 | VQLRAQEKVHEMEKE |
| 690 | MEKEHLNKVQTANEV |
| 813 | DLATRVKKSAEVDSD |
| 847 | EQLTKVHKQLVRDNA |
Function
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends. Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity)
Protein Sequence
10
MADPAECNIK
20
VMCRFRPLNE
30
SEVNRGDKYV
40
AKFQGEDTVM
50
IASKPYAFDR
60
VFQSSTSQEQ
70
VYNDCAKKIV
80
KDVLEGYNGT
90
IFAYGQTSSG
100
KTHTMEGKLH
110
DPEGMGIIPR
120
IVQDIFNYIY
130
SMDENLEFHI
140
KVSYFEIYLD
150
KIRDLLDVSK
160
TNLSVHEDKN
170
RVPYVKGCTE
180
RFVCSPDEVM
190
DTIDEGKSNR
200
HVAVTNMNEH
210
SSRSHSIFLI
220
NVKQENTQTE
230
QKLSGKLYLV
240
DLAGSEKVSK
250
TGAEGAVLDE
260
AKNINKSLSA
270
LGNVISALAE
280
GSTYVPYRDS
290
KMTRILQDSL
300
GGNCRTTIVI
310
CCSPSSYNES
320
ETKSTLLFGQ
330
RAKTIKNTVC
340
VNVELTAEQW
350
KKKYEKEKEK
360
NKTLRNTIQW
370
LENELNRWRN
380
GETVPIDEQF
390
DKEKANLEAF
400
TADKDVAITN
410
DKPAAAIGMA
420
GSFTDAERRK
430
CEEEIAKLYK
440
QLDDKDEEIN
450
QQSQLVEKLK
460
TQMLDQEELL
470
ASTRRDQDNM
480
QAELNRLQAE
490
NDASKEEVKE
500
VLQALEELAV
510
NYDQKSQEVE
520
DKTKEYELLS
530
DELNQKSATL
540
ASIDAELQKL
550
KEMTNHQKKR
560
AAEMMASLLK
570
DLAEIGIAVG
580
NNDVKQPEGT
590
GMIDEEFTVA
600
RLYISKMKSE
610
VKTMVKRCKQ
620
LESTQTESNK
630
KMEENEKELA
640
ACQLRISQHE
650
AKIKSLTEYL
660
QNVEQKKRQL
670
EESVDSLGEE
680
LVQLRAQEKV
690
HEMEKEHLNK
700
VQTANEVKQA
710
VEQQIQSHRE
720
THQKQISSLR
730
DEVEAKEKLI
740
TDLQDQNQKM
750
VLEQERLRVE
760
HERLKAVDQE
770
KSRKLHELTV
780
MQDRREQARQ
790
DLKGLEETVA
800
KELQTLHNLR
810
KLFVQDLATR
820
VKKSAEVDSD
830
DTGGSAAQKQ
840
KISFLENNLE
850
QLTKVHKQLV
860
RDNADLRCEL
870
PKLEKRLRAT
880
AERVKALESA
890
LKEAKENASR
900
DRKRYQQEVD
910
RIKEAVRSKN
920
MARRGHSAQI
930
AKPIRPGQHP
940
AASPTHPGAV
950
RGGGSFVQNN
960
QPVGLRGGGG
KQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0044295 | axonal growth cone |
| Cellular Component | GO:0035253 | ciliary rootlet |
| Cellular Component | GO:0101004 | cytolytic granule membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008432 | JUN kinase binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0099609 | microtubule lateral binding |
| Molecular Function | GO:0003777 | microtubule motor activity |
| Molecular Function | GO:0008574 | plus-end-directed microtubule motor activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0099641 | anterograde axonal protein transport |
| Biological Process | GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0051642 | centrosome localization |
| Biological Process | GO:0007028 | cytoplasm organization |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0032418 | lysosome localization |
| Biological Process | GO:0047497 | mitochondrion transport along microtubule |
| Biological Process | GO:0160040 | mitocytosis |
| Biological Process | GO:0042267 | natural killer cell mediated cytotoxicity |
| Biological Process | GO:0072383 | plus-end-directed vesicle transport along microtubule |
| Biological Process | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process | GO:0090316 | positive regulation of intracellular protein transport |
| Biological Process | GO:0043268 | positive regulation of potassium ion transport |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0032230 | positive regulation of synaptic transmission, GABAergic |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:1905152 | positive regulation of voltage-gated sodium channel activity |
| Biological Process | GO:0042391 | regulation of membrane potential |
| Biological Process | GO:0098987 | regulation of modification of synapse structure, modulating synaptic transmission |
| Biological Process | GO:1990049 | retrograde neuronal dense core vesicle transport |
| Biological Process | GO:0035617 | stress granule disassembly |
| Biological Process | GO:0048489 | synaptic vesicle transport |
| Biological Process | GO:0047496 | vesicle transport along microtubule |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.