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Overview

Uniprot IDQ2PS20
Protein NameJunctophilin-2
Gene NameJph2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
352 KRRVLPLKSNKVRQK

Function

Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions

Protein Sequence

10 MSGGRFDFDD 20 GGAYCGGWEG 30 GKAHGHGLCT 40 GPKGQGEYSG 50 SWNFGFEVAG 60 VYTWPSGNTF 70 EGYWSQGKRH 80 GLGIETKGRW 90 LYKGEWTHGF 100 KGRYGIRQST 110 NSGAKYEGTW 120 NNGLQDGYGT 130 ETYADGGTYQ 140 GQFTNGMRHG 150 YGVRQSVPYG 160 MAVVVRSPLR 170 TSLSSLRSEH 180 SNGTVAPDSP 190 AADGPTLPLP 200 PVPRGGFALS 210 LLATAEAARP 220 PGLFTRGALL 230 GRLRRSESRT 240 SLGSQRSRLS 250 FLKSELSSGA 260 SDAASTGSLA 270 EGAEGPDDAA 280 APFDADIDAT 290 TTETYMGEWK 300 NDKRSGFGVS 310 ERSSGLRYEG 320 EWLDNLRHGY 330 GRTTLPDGHR 340 EEGKYRHNVL 350 VKGTKRRVLP 360 LKSNKVRQKV 370 EHGVEGAQRA 380 AAIARQKAEI 390 AASRTSHAKA 400 KAEAAEQAAL 410 AANQESNIAR 420 TLAKELAPDF 430 YQPGPEYQKR 440 RLLQEILENS 450 ESLLEPRERG 460 PGTGLPERPR 470 ESPQLHERET 480 PQPEGGPPSP 490 AGTPPQPKRP 500 RPGSSKDGLL 510 SPGAWNGEPG 520 GEGSRPATPS 530 DGAGRRSPAR 540 PASEHMAIEA 550 LQPPPAPSRE 560 PEVALYRGYH 570 SYAVRTGPPE 580 PPPLEDEPEP 590 EPEVPRSDSE 600 PPSPVSATVQ 610 EEESPAPRSR 620 VPAKPATLEP 630 KPIVPKAEPK 640 AKARKTEARG 650 LSKAGAKKKG 660 RKEVAQEAEA 670 EVEVEEVPNT 680 VLICMVILLN 690 IGLAILFVHL LT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0030314 junctional membrane complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0070300 phosphatidic acid binding
Molecular Function GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
Molecular Function GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Molecular Function GO:0032266 phosphatidylinositol-3-phosphate binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Molecular Function GO:0070273 phosphatidylinositol-4-phosphate binding
Molecular Function GO:0010314 phosphatidylinositol-5-phosphate binding
Molecular Function GO:0001786 phosphatidylserine binding
Biological Process GO:0055074 calcium ion homeostasis
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0055024 regulation of cardiac muscle tissue development

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.