Search Results

Overview

Uniprot IDQ2TB10
Protein NameZinc finger protein 800
Gene NameZNF800
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
279 QSSKGRSKNVLVPLS
338 FLDSISPKKSFKTRK
339 LDSISPKKSFKTRKQ
351 RKQKSSSKAEYNLTA
392 TLSGTNSKREKGPNN
395 GTNSKREKGPNNTAN
471 SAAGGQQKTRKPKLS
571 PIDFVLNKVAKRGPS
613 GIEVKVTKNFSLHRC

Function

DNA-binding transcription repressor that acts as a master repressor of enteroendocrine cell differentiation (PubMed:37883554). Acts upstream of the endocrine gene network and directly represses expression of enteroendocrine transcription factors, such as NEUROG3, INSM1 and SOX4 (PubMed:37883554). In the intestine, prevents enterochromaffin cell differentiation by repressing expression of PAX4, a transcription factor that drives differentiation of enterochromaffin cell and restricts differentiation of other intestinal enteroendocrine cell types (PubMed:37883554). Also involved in the differentiation and development of type B pancreatic cells (By similarity)

Protein Sequence

10 MPLRDKYCQT 20 DHHHHGCCEP 30 VYILEPGDPP 40 LLQQPLQTSK 50 SGIQQIIECF 60 RSGTKQLKHI 70 LLKDVDTIFE 80 CKLCRSLFRG 90 LPNLITHKKF 100 YCPPSLQMDD 110 NLPDVNDKQS 120 QAINDLLEAI 130 YPSVDKREYI 140 IKLEPIETNQ 150 NAVFQYISRT 160 DNPIEVTESS 170 STPEQTEVQI 180 QETSTEQSKT 190 VPVTDTEVET 200 VEPPPVEIVT 210 DEVAPTSDEQ 220 PQESQADLET 230 SDNSDFGHQL 240 ICCLCRKEFN 250 SRRGVRRHIR 260 KVHKKKMEEL 270 KKYIETRKNP 280 NQSSKGRSKN 290 VLVPLSRSCP 300 VCCKSFATKA 310 NVRRHFDEVH 320 RGLRRDSITP 330 DIATKPGQPL 340 FLDSISPKKS 350 FKTRKQKSSS 360 KAEYNLTACK 370 CLLCKRKYSS 380 QIMLKRHMQI 390 VHKITLSGTN 400 SKREKGPNNT 410 ANSSEIKVKV 420 EPADSVESSP 430 PSITHSPQNE 440 LKGTNHSNEK 450 KNTPAAQKNK 460 VKQDSESPKS 470 TSPSAAGGQQ 480 KTRKPKLSAG 490 FDFKQLYCKL 500 CKRQFTSKQN 510 LTKHIELHTD 520 GNNIYVKFYK 530 CPLCTYETRR 540 KRDVIRHITV 550 VHKKSSRYLG 560 KITASLEIRA 570 IKKPIDFVLN 580 KVAKRGPSRD 590 EAKHSDSKHD 600 GTSNSPSKKY 610 EVADVGIEVK 620 VTKNFSLHRC 630 NKCGKAFAKK 640 TYLEHHKKTH 650 KANASNSPEG 660 NKTKGRSTRS KALV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:7770019 negative regulation of enteroendocrine cell differentiation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.