Search Results

Overview

Uniprot IDQ2TB90
Protein NameHexokinase HKDC1
Gene NameHKDC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 VQVAEEGKRHVQMES
15 AFYFSKLKEDQIKKV
315 LILLKMAKAGLLFGG
324 GLLFGGEKSSALHTK
331 KSSALHTKGKIETRH
346 VAAMEKYKEGLANTR
502 LEYGLKKKSHGLATV
527 PDGTEKGKFLALDLG
544 NFRVLLVKIRSGRRS
908 ALITAVAKRLQQAQK

Function

Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (PubMed:30517626). Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity)

Protein Sequence

10 MFAVHLMAFY 20 FSKLKEDQIK 30 KVDRFLYHMR 40 LSDDTLLDIM 50 RRFRAEMEKG 60 LAKDTNPTAA 70 VKMLPTFVRA 80 IPDGSENGEF 90 LSLDLGGSKF 100 RVLKVQVAEE 110 GKRHVQMESQ 120 FYPTPNEIIR 130 GNGTELFEYV 140 ADCLADFMKT 150 KDLKHKKLPL 160 GLTFSFPCRQ 170 TKLEEGVLLS 180 WTKKFKARGV 190 QDTDVVSRLT 200 KAMRRHKDMD 210 VDILALVNDT 220 VGTMMTCAYD 230 DPYCEVGVII 240 GTGTNACYME 250 DMSNIDLVEG 260 DEGRMCINTE 270 WGAFGDDGAL 280 EDIRTEFDRE 290 LDLGSLNPGK 300 QLFEKMISGL 310 YLGELVRLIL 320 LKMAKAGLLF 330 GGEKSSALHT 340 KGKIETRHVA 350 AMEKYKEGLA 360 NTREILVDLG 370 LEPSEADCIA 380 VQHVCTIVSF 390 RSANLCAAAL 400 AAILTRLREN 410 KKVERLRTTV 420 GMDGTLYKIH 430 PQYPKRLHKV 440 VRKLVPSCDV 450 RFLLSESGST 460 KGAAMVTAVA 470 SRVQAQRKQI 480 DRVLALFQLT 490 REQLVDVQAK 500 MRAELEYGLK 510 KKSHGLATVR 520 MLPTYVCGLP 530 DGTEKGKFLA 540 LDLGGTNFRV 550 LLVKIRSGRR 560 SVRMYNKIFA 570 IPLEIMQGTG 580 EELFDHIVQC 590 IADFLDYMGL 600 KGASLPLGFT 610 FSFPCRQMSI 620 DKGTLIGWTK 630 GFKATDCEGE 640 DVVDMLREAI 650 KRRNEFDLDI 660 VAVVNDTVGT 670 MMTCGYEDPN 680 CEIGLIAGTG 690 SNMCYMEDMR 700 NIEMVEGGEG 710 KMCINTEWGG 720 FGDNGCIDDI 730 WTRYDTEVDE 740 GSLNPGKQRY 750 EKMTSGMYLG 760 EIVRQILIDL 770 TKQGLLFRGQ 780 ISERLRTRGI 790 FETKFLSQIE 800 SDRLALLQVR 810 RILQQLGLDS 820 TCEDSIVVKE 830 VCGAVSRRAA 840 QLCGAGLAAI 850 VEKRREDQGL 860 EHLRITVGVD 870 GTLYKLHPHF 880 SRILQETVKE 890 LAPRCDVTFM 900 LSEDGSGKGA 910 ALITAVAKRL QQAQKEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031966 mitochondrial membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0001917 photoreceptor inner segment
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005536 D-glucose binding
Molecular Function GO:0008865 fructokinase activity
Molecular Function GO:0004340 glucokinase activity
Biological Process GO:0051156 glucose 6-phosphate metabolic process
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0001678 intracellular glucose homeostasis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.