Overview
| Uniprot ID | Q2TJZ7 |
|---|
| Protein Name | Prostaglandin E synthase |
|---|
| Gene Name | - |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 43 |
GQVRLRKKAFANPED |
Function
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively
Protein Sequence
10
MPPPSLEMVS
20
GQVLPAFLLC
30
STLLVIKMYV
40
VAIITGQVRL
50
RKKAFANPED
60
AQRHGGLQYC
70
RSDPDVERCL
80
RAHRNDMETI
90
YPFLFLGLVY
100
SFLGPDPFVA
110
WMHFLIFFLG
120
RMVHTIAYLG
130
KLRAPTRSLA
140
YTLAQLPCAS
150
MALQIVWEAA
RHL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005641 |
nuclear envelope lumen |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0043295 |
glutathione binding |
| Molecular Function |
GO:0004602 |
glutathione peroxidase activity |
| Molecular Function |
GO:0004364 |
glutathione transferase activity |
| Molecular Function |
GO:0004667 |
prostaglandin-D synthase activity |
| Molecular Function |
GO:0050220 |
prostaglandin-E synthase activity |
| Biological Process |
GO:0019371 |
cyclooxygenase pathway |
| Biological Process |
GO:0001516 |
prostaglandin biosynthetic process |
| Biological Process |
GO:0031620 |
regulation of fever generation |
| Biological Process |
GO:0019233 |
sensory perception of pain |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.