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Overview

Uniprot IDQ2TPA8
Protein NameHydroxysteroid dehydrogenase-like protein 2
Gene NameHsdl2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
298 VPEVKEEKLQLQEES
390 EETFRIVKDSLSDEV
470 MSGKLKIKGNIALAI
87 QINSAVEKAVEKFGG

Function

Has apparently no steroid dehydrogenase activity. Controls bile acid (BA) and lipid metabolism in response to nutritional cues

Protein Sequence

10 MLPNTGKLAG 20 CTVFITGASR 30 GIGKAIALKA 40 AKDGANIVIA 50 AKTTQKHPKL 60 LGTIYTAAEE 70 IEAAGGTALP 80 CVVDVRDEQQ 90 INSAVEKAVE 100 KFGGIDILVN 110 NASAISLTNT 120 LDTPTKRVDL 130 MMNVNTRGTY 140 LTSKACIPFL 150 KKSKVGHILN 160 LSPPLNLNPL 170 WFKQHCAYTI 180 AKYGMSMCVL 190 GMAEEFRGEI 200 AVNALWPRTA 210 IHTAAMDMLG 220 GSGVENQCRK 230 VDIIADAAYS 240 IFKRPKSFTG 250 NFIIDENILK 260 EEGIKNFDVY 270 AIAPGHPLLP 280 DFFLDEHPDA 290 VMEEKESNDS 300 VPEVKEEKLQ 310 LQEESQLQKQ 320 PQLQEQPQLQ 330 EKPQLQEKPQ 340 LQEQPQLQEK 350 PQLQEQPQQR 360 EQPQLQQQPR 370 PRQQPQPFVQ 380 SMLPQKPHFG 390 AVEETFRIVK 400 DSLSDEVVRA 410 TQAVYQFELS 420 GEDGGTWFLD 430 LKSKGGKVGH 440 GEPSDRADVV 450 MSMATDDFVK 460 MFSGKLKPTM 470 AFMSGKLKIK 480 GNIALAIKLE 490 KLMTQMNSRL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0016491 oxidoreductase activity
Biological Process GO:0042632 cholesterol homeostasis

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.