Search Results
Overview
| Uniprot ID | Q2TU34 |
|---|---|
| Protein Name | Fructose-1,6-bisphosphatase 1 |
| Gene Name | FBP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | VLVSEEDKHAIIVEP |
Function
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain
Protein Sequence
10
MADQAPFDTD
20
VNTLTRFVME
30
EGRKARGTGE
40
LTQLLNSLCT
50
AVKAISSAVR
60
KAGIAHLYGI
70
AGSTNVTGDQ
80
VKKLDVLSND
90
LVMNMLKSSF
100
ATCVLVSEED
110
KHAIIVEPEK
120
RGKYVVCFDP
130
LDGSSNIDCL
140
VSVGTIFGIY
150
RKKSTDEPSE
160
KDALQPGRNL
170
VAAGYALYGS
180
ATMLVLAMDC
190
GVNCFMLDPA
200
IGEFILVDKD
210
VKIKKKGKIY
220
SLNEGYAKDF
230
DPAVTEYIQR
240
KKFPPDNSAP
250
YGARYVGSMV
260
ADVHRTLVYG
270
GIFLYPANKK
280
SPNGKLRLLY
290
ECNPMAYVME
300
KAGGMATTGK
310
EAVLDVIPTD
320
IHQRAPVILG
330
SPDDVLEFLK
VYEKHSAQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0006094 | gluconeogenesis |
Reference
PMID: N/A