Search Results
Overview
| Uniprot ID | Q2XQ99 |
|---|---|
| Protein Name | Amyloid-beta A4 protein |
| Gene Name | APP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | KRSRKQCKTHTHIVI |
| 134 | LLVPDKCKFLHQERM |
| 60 | ESDPSGTKTCIGTKE |
Function
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis
Protein Sequence
10
MLPGLALVLL
20
AAWTARALEV
30
PTDGNAGLLA
40
EPQVAMFCGK
50
LNMHMNVQNG
60
KWESDPSGTK
70
TCIGTKEGIL
80
QYCQEVYPEL
90
QITNVVEANQ
100
PVTIQNWCKR
110
SRKQCKTHTH
120
IVIPYRCLVG
130
EFVSDALLVP
140
DKCKFLHQER
150
MDVCETHLHW
160
HTVAKETCSE
170
KSTNLHDYGM
180
LLPCGIDKFR
190
GVEFVCCPLA
200
EESDNIDSAD
210
AEEDDSDVWW
220
GGADTDYADG
230
SEDKVVEVAE
240
EEEVADVEEE
250
EAEDDEDDED
260
GDEVEEEAEE
270
PYEEATERTT
280
SIATTTTTTT
290
ESVEEVVREV
300
CSEQAETGPC
310
RAMISRWYFD
320
VTEGKCAPFF
330
YGGCGGNRNN
340
FDTEEYCMAV
350
CGSVIPTTAA
360
STPDAVDKYL
370
ETPGDENEHA
380
HFQKAKERLE
390
AKHRERMSQV
400
MREWEEAERQ
410
AKNLPKADKK
420
AVIQHFQEKV
430
ESLEQEAANE
440
RQQLVETHMA
450
RVEAMLNDRR
460
RLALENYITA
470
LQAVPPRPRH
480
VFNMLKKYVR
490
AEQKDRQHTL
500
KHFEHVRMVD
510
PKKAAQIRSQ
520
VMTHLRVIYE
530
RMNQSLSLLY
540
NVPAVAEEIQ
550
DEVDELLQKE
560
QNYSDDVLAN
570
MISEPRISYG
580
NDALMPSLTE
590
TKTTVELLPV
600
NGEFSLDDLQ
610
PWHPFGVDSV
620
PANTENEVEP
630
VDARPAADRG
640
LTTRPGSGLT
650
NIKTEEISEV
660
KMDAEFRHDS
670
GYEVHHQKLV
680
FFAEDVGSNK
690
GAIIGLMVGG
700
VVIATVIVIT
710
LVMLKKKQYT
720
SIHHGVVEVD
730
AAVTPEERHL
740
SKMQQNGYEN
750
PTYKFFEQMQ
N
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0007155 | cell adhesion |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005798 | Golgi-associated vesicle |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099503 | secretory vesicle |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0046914 | transition metal ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0007219 | Notch signaling pathway |
| Biological Process | GO:0010604 | positive regulation of macromolecule metabolic process |
| Biological Process | GO:0051246 | regulation of protein metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.