Search Results
Overview
| Uniprot ID | Q2XQA0 |
|---|---|
| Protein Name | Amyloid-beta A4 protein |
| Gene Name | APP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | KRSRKQCKTHTHIVI |
| 134 | LLVPDKCKFLHQERM |
| 60 | ESDPSGTKTCIGTKE |
Function
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis
Protein Sequence
10
MLPGLALVLL
20
AAWTARALEV
30
PTDGNAGLLA
40
EPQVAMFCGK
50
LNMHMNVQNG
60
KWESDPSGTK
70
TCIGTKEGIL
80
QYCQEVYPEL
90
QITNVVEANQ
100
PVTIQNWCKR
110
SRKQCKTHTH
120
IVIPYRCLVG
130
EFVSDALLVP
140
DKCKFLHQER
150
MDVCETHLHW
160
HTVAKETCSE
170
KSTNLHDYGM
180
LLPCGIDKFR
190
GVEFVCCPLA
200
EESDNIDSAD
210
AEEDDSDVWW
220
GGADTDYADG
230
SEDKVVEVAE
240
EEEVADVEEE
250
EAEDDEDDED
260
GDEVEEEAEE
270
PYEEATERTT
280
SIATTTTTTT
290
ESVEEVVRVP
300
TTAASTPDAV
310
DKYLETPGDE
320
NEHAHFQKAK
330
ERLEAKHRER
340
MSQVMREWEE
350
AERQAKNLPK
360
ADKKAVIQHF
370
QEKVESLEQE
380
AANERQQLVE
390
THMARVEAML
400
NDRRRLALEN
410
YITALQAVPP
420
RPRHVFNMLK
430
KYVRAEQKDR
440
QHTLKHFEHV
450
RMVDPKKAAQ
460
IRSQVMTHLR
470
VIYERMNQSL
480
SLLYNVPAVA
490
EEIQDEVDEL
500
LQKEQNYSDD
510
VLANMISEPR
520
ISYGNDALMP
530
SLTETKTTVE
540
LLPVNGEFSL
550
DDLQPWHPFG
560
VDSVPANTEN
570
EVEPVDARPA
580
ADRGLTTRPG
590
SGLTNIKTEE
600
ISEVKMDAEF
610
RHDSGYEVHH
620
QKLVFFAEDV
630
GSNKGAIIGL
640
MVGGVVIATV
650
IVITLVMLKK
660
KQYTSIHHGV
670
VEVDAAVTPE
680
ERHLSKMQQN
690
GYENPTYKFF
EQMQN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005798 | Golgi-associated vesicle |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099503 | secretory vesicle |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0046914 | transition metal ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0010604 | positive regulation of macromolecule metabolic process |
| Biological Process | GO:0051246 | regulation of protein metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.