Search Results
Overview
| Uniprot ID | Q2XQV4 |
|---|---|
| Protein Name | Aldehyde dehydrogenase, mitochondrial |
| Gene Name | ALDH2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | WADKYHGKTLPIDGD |
| 387 | SGKEEGAKLLCGGGA |
| 432 | VMQILKFKTIEEVIG |
| 515 | EVKTVTVKVPQKNS* |
| 56 | WHDAISKKTFPTVNP |
Function
Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage
Protein Sequence
10
MLRPAALAAA
20
RLVLRQGRRL
30
LSAAPTQAVP
40
APNQQPEIFY
50
NQIFINNEWH
60
DAISKKTFPT
70
VNPSTGDVIC
80
HVAEGDKEDV
90
DRAVEAARAA
100
FQLGSPWRRL
110
DASDRGRLLN
120
RLADLIERDR
130
TYLAALETLD
140
NGKPYVISYL
150
VDLDMVLKCL
160
RYYAGWADKY
170
HGKTLPIDGD
180
YFSYTRHEPV
190
GVCGQIIPWN
200
FPLLMQAWKL
210
GPALATGNVV
220
VMKVSEQTPL
230
TALYVANLIK
240
EAGFPPGVVN
250
IVPGYGPTAG
260
AAIASHEDVD
270
KVAFTGSTEV
280
GHLIQVAAGK
290
SNLKRVTLEL
300
GGKSPNIIMS
310
DADMDWAVEQ
320
AHFALFFNQG
330
QCCCAGSRTF
340
VQEDIYAEFV
350
ERSVARARSR
360
VVGNPFDSRT
370
EQGPQIDETQ
380
FKKILGYIKS
390
GKEEGAKLLC
400
GGGAAADRGY
410
FIQPTVFGDV
420
QDGMTIAKEE
430
IFGPVMQILK
440
FKTIEEVIGR
450
ANNSKYGLAA
460
AVFTKDLDKA
470
NYLSQALQAG
480
TVWVNCYDVF
490
GAQSPFGGYK
500
LSGSGRELGE
510
YGLQAYTEVK
520
TVTVKVPQKN
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004029 | aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0106435 | carboxylesterase activity |
| Molecular Function | GO:0008957 | phenylacetaldehyde dehydrogenase (NAD+) activity |
| Biological Process | GO:0046185 | aldehyde catabolic process |
| Biological Process | GO:0110095 | cellular detoxification of aldehyde |
| Biological Process | GO:0006068 | ethanol catabolic process |
| Biological Process | GO:0006067 | ethanol metabolic process |
| Biological Process | GO:0018937 | nitroglycerin metabolic process |
| Biological Process | GO:1903179 | regulation of dopamine biosynthetic process |
| Biological Process | GO:1905627 | regulation of serotonin biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.