Overview
| Uniprot ID | Q2XSV9 |
|---|
| Protein Name | Guanine nucleotide-binding protein subunit alpha-11 |
|---|
| Gene Name | GNA11 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 120 |
IREVDVEKVTTFEHR |
| 276 |
VILFLNKKDLLEDKI |
Function
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNAQ, required for heart development (By similarity). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens
Protein Sequence
10
MTLESMMACC
20
LSDEVKESKR
30
INAEIEKQLR
40
RDKRDARREL
50
KLLLLGTGES
60
GKSTFIKQMR
70
IIHGAGYSEE
80
DKRGFTKLVY
90
QNIFTAMQAM
100
IRAMETLKIL
110
YKYEQNKANA
120
LLIREVDVEK
130
VTTFEHRYVS
140
AIKTLWNDPG
150
IQECYDRRRE
160
YQLSDSAKYY
170
LTDVDRIATS
180
GYLPTQQDVL
190
RVRVPTTGII
200
EYPFDLENII
210
FRMVDVGGQR
220
SERRKWIHCF
230
ENVTSIMFLV
240
ALSEYDQVLV
250
ESDNENRMEE
260
SKALFRTIVT
270
YPWFQNSSVI
280
LFLNKKDLLE
290
DKILFSHLVD
300
YFPEFDGPQR
310
VAQAAREFIL
320
KMFVDLNPDS
330
DKIIYSHFTC
340
ATDTENIRFV
350
FAAVKDTILQ
LNLKEYNLV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005834 |
heterotrimeric G-protein complex |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0001750 |
photoreceptor outer segment |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0001664 |
G protein-coupled receptor binding |
| Molecular Function |
GO:0031683 |
G-protein beta/gamma-subunit complex binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0001508 |
action potential |
| Biological Process |
GO:0007188 |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0009649 |
entrainment of circadian clock |
| Biological Process |
GO:0007213 |
G protein-coupled acetylcholine receptor signaling pathway |
| Biological Process |
GO:0060158 |
phospholipase C-activating dopamine receptor signaling pathway |
| Biological Process |
GO:0007603 |
phototransduction, visible light |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.